a tool for identifying drug-targetable redox-active disulphides

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

Intermolecular

Cysteine 423 of Transcription activator BRG1 and cysteine 492 L

A redox-regulated disulphide may form between cysteine 423 of Transcription activator BRG1 and cysteine 492 of SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

41

PDB code

Structure name

the nucleosome-bound human pbaf complex

Structure deposition date

2022-06-24

Thiol separation (Å)

10

Half-sphere exposure sum ?

44

Minimum pK_a ?

8

% buried

34

Peptide A name

Transcription activator BRG1

Peptide B name

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

Peptide A accession

Peptide B accession

Peptide A residue number

423

Peptide B residue number

492

Ligandability

Cysteine 423 of Transcription activator BRG1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 492 of SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

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