ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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GTP-binding protein Di-Ras2

Intramolecular
Cysteine 50 and cysteine 55
Cysteine 105 and cysteine 145
A redox-regulated disulphide may form within GTP-binding protein Di-Ras2 between cysteines 50 and 55.

Details

Redox score ?
80
PDB code
2erx
Structure name
crystal structure of diras2 in complex with gdp and inorganic phosphate
Structure deposition date
2005-10-25
Thiol separation (Å)
4
Half-sphere exposure sum ?
48
Minimum pKa ?
9
% buried
11
Peptide accession
Q96HU8
Residue number A
50
Residue number B
55
Peptide name
GTP-binding protein Di-Ras2

Ligandability

Cysteine 50 of GTP-binding protein Di-Ras2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 55 of GTP-binding protein Di-Ras2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GTP-binding protein Di-Ras2 between cysteines 105 and 145. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
2erx
Structure name
crystal structure of diras2 in complex with gdp and inorganic phosphate
Structure deposition date
2005-10-25
Thiol separation (Å)
9
Half-sphere exposure sum ?
48
Minimum pKa ?
9
% buried
30
Peptide accession
Q96HU8
Residue number A
105
Residue number B
145
Peptide name
GTP-binding protein Di-Ras2

Ligandability

Cysteine 105 of GTP-binding protein Di-Ras2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 145 of GTP-binding protein Di-Ras2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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