ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

Intramolecular
Cysteine 247 and cysteine 280 L
Cysteine 247 and cysteine 283 L
Cysteine 247 and cysteine 250
Cysteine 250 and cysteine 283 L
Cysteine 250 and cysteine 280 L
Cysteine 306 and cysteine 352 L
Cysteine 280 and cysteine 283 L
Cysteine 349 and cysteine 356 L
Cysteine 312 and cysteine 316
Cysteine 194 and cysteine 316
More...
Cysteine 317 and cysteine 349 L
Cysteine 316 and cysteine 317
Cysteine 194 and cysteine 312
Cysteine 21 and cysteine 74
Cysteine 317 and cysteine 356 L
A redox-regulated disulphide may form within Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase between cysteines 247 and 280.

Details

Redox score ?
90
PDB code
2f4m
Structure name
the mouse pngase-hr23 complex reveals a complete remodulation of the protein-protein interface compared to its yeast orthologs
Structure deposition date
2005-11-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
50
Minimum pKa ?
5
% buried
0
Peptide accession
Q9JI78
Residue number A
247
Residue number B
280
Peptide name
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

Ligandability

Cysteine 247 of Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 280 of Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase between cysteines 247 and 283.

Details

Redox score ?
89
PDB code
2f4m
Structure name
the mouse pngase-hr23 complex reveals a complete remodulation of the protein-protein interface compared to its yeast orthologs
Structure deposition date
2005-11-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
43
Minimum pKa ?
5
% buried
0
Peptide accession
Q9JI78
Residue number A
247
Residue number B
283
Peptide name
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

Ligandability

Cysteine 247 of Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 283 of Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase between cysteines 247 and 250.

Details

Redox score ?
89
PDB code
2f4m
Structure name
the mouse pngase-hr23 complex reveals a complete remodulation of the protein-protein interface compared to its yeast orthologs
Structure deposition date
2005-11-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
43
Minimum pKa ?
5
% buried
0
Peptide accession
Q9JI78
Residue number A
247
Residue number B
250
Peptide name
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

Ligandability

Cysteine 247 of Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 250 of Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase between cysteines 250 and 283.

Details

Redox score ?
82
PDB code
2f4m
Structure name
the mouse pngase-hr23 complex reveals a complete remodulation of the protein-protein interface compared to its yeast orthologs
Structure deposition date
2005-11-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
36
Minimum pKa ?
8
% buried
0
Peptide accession
Q9JI78
Residue number A
250
Residue number B
283
Peptide name
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

Ligandability

Cysteine 250 of Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 283 of Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase between cysteines 250 and 280.

Details

Redox score ?
82
PDB code
2f4m
Structure name
the mouse pngase-hr23 complex reveals a complete remodulation of the protein-protein interface compared to its yeast orthologs
Structure deposition date
2005-11-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
43
Minimum pKa ?
8
% buried
0
Peptide accession
Q9JI78
Residue number A
250
Residue number B
280
Peptide name
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

Ligandability

Cysteine 250 of Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 280 of Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase between cysteines 306 and 352.

Details

Redox score ?
82
PDB code
2f4m
Structure name
the mouse pngase-hr23 complex reveals a complete remodulation of the protein-protein interface compared to its yeast orthologs
Structure deposition date
2005-11-23
Thiol separation (Å)
2
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9JI78
Residue number A
306
Residue number B
352
Peptide name
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

Ligandability

Cysteine 306 of Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 352 of Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase between cysteines 280 and 283.

Details

Redox score ?
80
PDB code
2f4m
Structure name
the mouse pngase-hr23 complex reveals a complete remodulation of the protein-protein interface compared to its yeast orthologs
Structure deposition date
2005-11-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
43
Minimum pKa ?
9
% buried
0
Peptide accession
Q9JI78
Residue number A
280
Residue number B
283
Peptide name
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

Ligandability

Cysteine 280 of Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 283 of Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase between cysteines 349 and 356.

Details

Redox score ?
71
PDB code
2f4m
Structure name
the mouse pngase-hr23 complex reveals a complete remodulation of the protein-protein interface compared to its yeast orthologs
Structure deposition date
2005-11-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
69
Minimum pKa ?
8
% buried
93
Peptide accession
Q9JI78
Residue number A
349
Residue number B
356
Peptide name
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

Ligandability

Cysteine 349 of Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 356 of Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase between cysteines 312 and 316. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
60
PDB code
2f4m
Structure name
the mouse pngase-hr23 complex reveals a complete remodulation of the protein-protein interface compared to its yeast orthologs
Structure deposition date
2005-11-23
Thiol separation (Å)
5
Half-sphere exposure sum ?
97
Minimum pKa ?
9
% buried
100
Peptide accession
Q9JI78
Residue number A
312
Residue number B
316
Peptide name
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

Ligandability

Cysteine 312 of Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 316 of Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase between cysteines 194 and 316. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
2f4m
Structure name
the mouse pngase-hr23 complex reveals a complete remodulation of the protein-protein interface compared to its yeast orthologs
Structure deposition date
2005-11-23
Thiol separation (Å)
7
Half-sphere exposure sum ?
72
Minimum pKa ?
9
% buried
69
Peptide accession
Q9JI78
Residue number A
194
Residue number B
316
Peptide name
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

Ligandability

Cysteine 194 of Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 316 of Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase between cysteines 317 and 349. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
2f4m
Structure name
the mouse pngase-hr23 complex reveals a complete remodulation of the protein-protein interface compared to its yeast orthologs
Structure deposition date
2005-11-23
Thiol separation (Å)
6
Half-sphere exposure sum ?
80
Minimum pKa ?
13
% buried
100
Peptide accession
Q9JI78
Residue number A
317
Residue number B
349
Peptide name
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

Ligandability

Cysteine 317 of Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 349 of Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase between cysteines 316 and 317. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
2f4m
Structure name
the mouse pngase-hr23 complex reveals a complete remodulation of the protein-protein interface compared to its yeast orthologs
Structure deposition date
2005-11-23
Thiol separation (Å)
7
Half-sphere exposure sum ?
85
Minimum pKa ?
9
% buried
100
Peptide accession
Q9JI78
Residue number A
316
Residue number B
317
Peptide name
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

Ligandability

Cysteine 316 of Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 317 of Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase between cysteines 194 and 312. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
2f4m
Structure name
the mouse pngase-hr23 complex reveals a complete remodulation of the protein-protein interface compared to its yeast orthologs
Structure deposition date
2005-11-23
Thiol separation (Å)
7
Half-sphere exposure sum ?
80
Minimum pKa ?
10
% buried
69
Peptide accession
Q9JI78
Residue number A
194
Residue number B
312
Peptide name
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

Ligandability

Cysteine 194 of Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 312 of Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase between cysteines 21 and 74. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
2hpl
Structure name
crystal structure of the mouse p97/pngase complex
Structure deposition date
2006-07-17
Thiol separation (Å)
8
Half-sphere exposure sum ?
69
Minimum pKa ?
10
% buried
44
Peptide accession
Q9JI78
Residue number A
21
Residue number B
74
Peptide name
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

Ligandability

Cysteine 21 of Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 74 of Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase between cysteines 317 and 356. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
2f4m
Structure name
the mouse pngase-hr23 complex reveals a complete remodulation of the protein-protein interface compared to its yeast orthologs
Structure deposition date
2005-11-23
Thiol separation (Å)
10
Half-sphere exposure sum ?
69
Minimum pKa ?
8
% buried
93
Peptide accession
Q9JI78
Residue number A
317
Residue number B
356
Peptide name
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

Ligandability

Cysteine 317 of Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 356 of Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: