ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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E3 ubiquitin-protein ligase Itchy homolog

Intramolecular
Cysteine 783 and cysteine 835
Cysteine 582 and cysteine 832
A redox-regulated disulphide may form within E3 ubiquitin-protein ligase Itchy homolog between cysteines 783 and 835.

Details

Redox score ?
71
PDB code
3tug
Structure name
crystal structure of the hect domain of itch e3 ubiquitin ligase
Structure deposition date
2011-09-16
Thiol separation (Å)
4
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96J02
Residue number A
783
Residue number B
835
Peptide name
E3 ubiquitin-protein ligase Itchy homolog

Ligandability

Cysteine 783 of E3 ubiquitin-protein ligase Itchy homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 835 of E3 ubiquitin-protein ligase Itchy homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within E3 ubiquitin-protein ligase Itchy between cysteines 582 and 832. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
5xmc
Structure name
crystal structure of the auto-inhibited nedd4 family e3 ligase itch
Structure deposition date
2017-05-13
Thiol separation (Å)
10
Half-sphere exposure sum ?
76
Minimum pKa ?
11
% buried
58
Peptide accession
Q8C863
Residue number A
582
Residue number B
832
Peptide name
E3 ubiquitin-protein ligase Itchy

Ligandability

Cysteine 582 of E3 ubiquitin-protein ligase Itchy

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 832 of E3 ubiquitin-protein ligase Itchy

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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