ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Kin of IRRE-like protein 1

Intramolecular
Cysteine 175 and cysteine 232
Cysteine 74 and cysteine 132
A redox-regulated disulphide may form within Kin of IRRE-like protein 1 between cysteines 175 and 232 (147 and 204 respectively in this structure).

Details

Redox score ?
81
PDB code
4ofd
Structure name
crystal structure of mouse neph1 d1-d2
Structure deposition date
2014-01-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q80W68
Residue number A
175
Residue number B
232
Peptide name
Kin of IRRE-like protein 1

Ligandability

Cysteine 175 of Kin of IRRE-like protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 232 of Kin of IRRE-like protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Kin of IRRE-like protein 1 between cysteines 74 and 132 (46 and 104 respectively in this structure).

Details

Redox score ?
80
PDB code
4ofd
Structure name
crystal structure of mouse neph1 d1-d2
Structure deposition date
2014-01-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q80W68
Residue number A
74
Residue number B
132
Peptide name
Kin of IRRE-like protein 1

Ligandability

Cysteine 74 of Kin of IRRE-like protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 132 of Kin of IRRE-like protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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