ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Leucine-rich repeats and immunoglobulin-like domains protein 1

Intramolecular
Cysteine 1 and cysteine 47
Cysteine 45 and cysteine 54
Cysteine 444 and cysteine 468
Cysteine 446 and cysteine 489
Cysteine 620 and cysteine 672
Cysteine 714 and cysteine 763
Cysteine 516 and cysteine 577
Cysteine 1 and cysteine 45
Cysteine 45 and cysteine 47
Cysteine 1 and cysteine 54
Cysteine 47 and cysteine 54
A redox-regulated disulphide may form within Leucine-rich repeats and immunoglobulin-like domains protein 1 between cysteines 1 and 47 (1 and 7 respectively in this structure).

Details

Redox score ?
91
PDB code
4u7l
Structure name
lrig1 extracellular domain: structure and function analysis
Structure deposition date
2014-07-31
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96JA1
Residue number A
1
Residue number B
47
Peptide name
Leucine-rich repeats and immunoglobulin-like domains protein 1

Ligandability

Cysteine 1 of Leucine-rich repeats and immunoglobulin-like domains protein 1

Cysteine 47 of Leucine-rich repeats and immunoglobulin-like domains protein 1

Cysteine 1 in protein A could not be asigned to a Uniprot residue.
A redox-regulated disulphide may form within Leucine-rich repeats and immunoglobulin-like domains protein 1 between cysteines 45 and 54 (5 and 14 respectively in this structure).

Details

Redox score ?
86
PDB code
4u7l
Structure name
lrig1 extracellular domain: structure and function analysis
Structure deposition date
2014-07-31
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96JA1
Residue number A
45
Residue number B
54
Peptide name
Leucine-rich repeats and immunoglobulin-like domains protein 1

Ligandability

Cysteine 45 of Leucine-rich repeats and immunoglobulin-like domains protein 1

Cysteine 54 of Leucine-rich repeats and immunoglobulin-like domains protein 1

A redox-regulated disulphide may form within Leucine-rich repeats and immunoglobulin-like domains protein 1 between cysteines 444 and 468 (404 and 428 respectively in this structure).

Details

Redox score ?
84
PDB code
4u7l
Structure name
lrig1 extracellular domain: structure and function analysis
Structure deposition date
2014-07-31
Thiol separation (Å)
2
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96JA1
Residue number A
444
Residue number B
468
Peptide name
Leucine-rich repeats and immunoglobulin-like domains protein 1

Ligandability

Cysteine 444 of Leucine-rich repeats and immunoglobulin-like domains protein 1

Cysteine 468 of Leucine-rich repeats and immunoglobulin-like domains protein 1

A redox-regulated disulphide may form within Leucine-rich repeats and immunoglobulin-like domains protein 1 between cysteines 446 and 489 (406 and 449 respectively in this structure).

Details

Redox score ?
84
PDB code
4u7l
Structure name
lrig1 extracellular domain: structure and function analysis
Structure deposition date
2014-07-31
Thiol separation (Å)
2
Half-sphere exposure sum ?
45
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96JA1
Residue number A
446
Residue number B
489
Peptide name
Leucine-rich repeats and immunoglobulin-like domains protein 1

Ligandability

Cysteine 446 of Leucine-rich repeats and immunoglobulin-like domains protein 1

Cysteine 489 of Leucine-rich repeats and immunoglobulin-like domains protein 1

A redox-regulated disulphide may form within Leucine-rich repeats and immunoglobulin-like domains protein 1 between cysteines 620 and 672.

Details

Redox score ?
83
PDB code
4u7m
Structure name
lrig1 extracellular domain: structure and function analysis
Structure deposition date
2014-07-31
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96JA1
Residue number A
620
Residue number B
672
Peptide name
Leucine-rich repeats and immunoglobulin-like domains protein 1

Ligandability

Cysteine 620 of Leucine-rich repeats and immunoglobulin-like domains protein 1

Cysteine 672 of Leucine-rich repeats and immunoglobulin-like domains protein 1

A redox-regulated disulphide may form within Leucine-rich repeats and immunoglobulin-like domains protein 1 between cysteines 714 and 763.

Details

Redox score ?
82
PDB code
4u7m
Structure name
lrig1 extracellular domain: structure and function analysis
Structure deposition date
2014-07-31
Thiol separation (Å)
2
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96JA1
Residue number A
714
Residue number B
763
Peptide name
Leucine-rich repeats and immunoglobulin-like domains protein 1

Ligandability

Cysteine 714 of Leucine-rich repeats and immunoglobulin-like domains protein 1

Cysteine 763 of Leucine-rich repeats and immunoglobulin-like domains protein 1

A redox-regulated disulphide may form within Leucine-rich repeats and immunoglobulin-like domains protein 1 between cysteines 516 and 577.

Details

Redox score ?
80
PDB code
4u7m
Structure name
lrig1 extracellular domain: structure and function analysis
Structure deposition date
2014-07-31
Thiol separation (Å)
2
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96JA1
Residue number A
516
Residue number B
577
Peptide name
Leucine-rich repeats and immunoglobulin-like domains protein 1

Ligandability

Cysteine 516 of Leucine-rich repeats and immunoglobulin-like domains protein 1

Cysteine 577 of Leucine-rich repeats and immunoglobulin-like domains protein 1

A redox-regulated disulphide may form within Leucine-rich repeats and immunoglobulin-like domains protein 1 between cysteines 1 and 45 (1 and 5 respectively in this structure).

Details

Redox score ?
64
PDB code
4u7l
Structure name
lrig1 extracellular domain: structure and function analysis
Structure deposition date
2014-07-31
Thiol separation (Å)
7
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96JA1
Residue number A
1
Residue number B
45
Peptide name
Leucine-rich repeats and immunoglobulin-like domains protein 1

Ligandability

Cysteine 1 of Leucine-rich repeats and immunoglobulin-like domains protein 1

Cysteine 45 of Leucine-rich repeats and immunoglobulin-like domains protein 1

Cysteine 1 in protein A could not be asigned to a Uniprot residue.
A redox-regulated disulphide may form within Leucine-rich repeats and immunoglobulin-like domains protein 1 between cysteines 45 and 47 (5 and 7 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
59
PDB code
4u7l
Structure name
lrig1 extracellular domain: structure and function analysis
Structure deposition date
2014-07-31
Thiol separation (Å)
7
Half-sphere exposure sum ?
48
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96JA1
Residue number A
45
Residue number B
47
Peptide name
Leucine-rich repeats and immunoglobulin-like domains protein 1

Ligandability

Cysteine 45 of Leucine-rich repeats and immunoglobulin-like domains protein 1

Cysteine 47 of Leucine-rich repeats and immunoglobulin-like domains protein 1

A redox-regulated disulphide may form within Leucine-rich repeats and immunoglobulin-like domains protein 1 between cysteines 1 and 54 (1 and 14 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
56
PDB code
4u7l
Structure name
lrig1 extracellular domain: structure and function analysis
Structure deposition date
2014-07-31
Thiol separation (Å)
8
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96JA1
Residue number A
1
Residue number B
54
Peptide name
Leucine-rich repeats and immunoglobulin-like domains protein 1

Ligandability

Cysteine 1 of Leucine-rich repeats and immunoglobulin-like domains protein 1

Cysteine 54 of Leucine-rich repeats and immunoglobulin-like domains protein 1

Cysteine 1 in protein A could not be asigned to a Uniprot residue.
A redox-regulated disulphide may form within Leucine-rich repeats and immunoglobulin-like domains protein 1 between cysteines 47 and 54 (7 and 14 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
4u7l
Structure name
lrig1 extracellular domain: structure and function analysis
Structure deposition date
2014-07-31
Thiol separation (Å)
7
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96JA1
Residue number A
47
Residue number B
54
Peptide name
Leucine-rich repeats and immunoglobulin-like domains protein 1

Ligandability

Cysteine 47 of Leucine-rich repeats and immunoglobulin-like domains protein 1

Cysteine 54 of Leucine-rich repeats and immunoglobulin-like domains protein 1

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