a tool for identifying drug-targetable redox-active disulphides

ELL-associated factor 1

Intermolecular

Cysteine 19 of RNA polymerase II elongation factor ELL2 and cysteine 46

A redox-regulated disulphide may form between cysteine 19 of RNA polymerase II elongation factor ELL2 and cysteine 46 of ELL-associated factor 1. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

55

PDB code

Structure name

structure of active transcription elongation complex pol ii-dsif (spt5-kow5)-ell2-eaf1 (composite structure)

Structure deposition date

2021-05-18

Thiol separation (Å)

9

Half-sphere exposure sum ?

nan

Minimum pK_a ?

9

% buried

18

Peptide A name

RNA polymerase II elongation factor ELL2

Peptide B name

ELL-associated factor 1

Peptide A accession

Peptide B accession

Peptide A residue number

19

Peptide B residue number

46

Ligandability

Cysteine 19 of RNA polymerase II elongation factor ELL2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 46 of ELL-associated factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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