ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Lethal(3)malignant brain tumor-like protein 3

Intramolecular
Cysteine 389 and cysteine 429
Cysteine 290 and cysteine 533
Cysteine 282 and cysteine 322
A redox-regulated disulphide may form within Lethal(3)malignant brain tumor-like protein 3 between cysteines 389 and 429. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
4fl6
Structure name
crystal structure of the complex of the 3-mbt repeat domain of l3mbtl3 and unc1215
Structure deposition date
2012-06-14
Thiol separation (Å)
8
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96JM7
Residue number A
389
Residue number B
429
Peptide name
Lethal(3)malignant brain tumor-like protein 3

Ligandability

Cysteine 389 of Lethal(3)malignant brain tumor-like protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 429 of Lethal(3)malignant brain tumor-like protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Lethal(3)malignant brain tumor-like protein 3 between cysteines 290 and 533. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
4l59
Structure name
crystal structure of the 3-mbt repeat domain of l3mbtl3 and unc2533 complex
Structure deposition date
2013-06-10
Thiol separation (Å)
8
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96JM7
Residue number A
290
Residue number B
533
Peptide name
Lethal(3)malignant brain tumor-like protein 3

Ligandability

Cysteine 290 of Lethal(3)malignant brain tumor-like protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 533 of Lethal(3)malignant brain tumor-like protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Lethal(3)malignant brain tumor-like protein 3 between cysteines 282 and 322. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
4l59
Structure name
crystal structure of the 3-mbt repeat domain of l3mbtl3 and unc2533 complex
Structure deposition date
2013-06-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96JM7
Residue number A
282
Residue number B
322
Peptide name
Lethal(3)malignant brain tumor-like protein 3

Ligandability

Cysteine 282 of Lethal(3)malignant brain tumor-like protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 322 of Lethal(3)malignant brain tumor-like protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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