a tool for identifying drug-targetable redox-active disulphides

Neuralized-like protein 4

Intramolecular

Cysteine 133 and cysteine 178

A redox-regulated disulphide may form within Neuralized-like protein 4 between cysteines 133 and 178 (98 and 143 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

38

PDB code

Structure name

solution structure of the neuz domain in kiaa1787 protein

Structure deposition date

2006-12-25

Thiol separation (Å)

10

Half-sphere exposure sum ?

53

Minimum pK_a ?

11

% buried

16

Peptide accession

Residue number A

133

Residue number B

178

Peptide name

Neuralized-like protein 4

Ligandability

Cysteine 133 of Neuralized-like protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 178 of Neuralized-like protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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