ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Hematopoietic SH2 domain-containing protein

Intramolecular
Cysteine 77 and cysteine 78
Cysteine 77 and cysteine 125
A redox-regulated disulphide may form within Hematopoietic SH2 domain-containing protein between cysteines 77 and 78 (61 and 62 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
58
PDB code
2cs0
Structure name
solution structure of the sh2 domain of human hsh2d protein
Structure deposition date
2005-05-20
Thiol separation (Å)
7
Half-sphere exposure sum ?
62
Minimum pKa ?
10
% buried
34
Peptide accession
Q96JZ2
Residue number A
77
Residue number B
78
Peptide name
Hematopoietic SH2 domain-containing protein

Ligandability

Cysteine 77 of Hematopoietic SH2 domain-containing protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 78 of Hematopoietic SH2 domain-containing protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Hematopoietic SH2 domain-containing protein between cysteines 77 and 125 (61 and 109 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
2cs0
Structure name
solution structure of the sh2 domain of human hsh2d protein
Structure deposition date
2005-05-20
Thiol separation (Å)
10
Half-sphere exposure sum ?
64
Minimum pKa ?
10
% buried
38
Peptide accession
Q96JZ2
Residue number A
77
Residue number B
125
Peptide name
Hematopoietic SH2 domain-containing protein

Ligandability

Cysteine 77 of Hematopoietic SH2 domain-containing protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 125 of Hematopoietic SH2 domain-containing protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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