a tool for identifying drug-targetable redox-active disulphides

Lymphokine-activated killer T-cell-originated protein kinase

Intermolecular

Cysteine 70 and cysteine 70

A redox-regulated disulphide may form between two units of Lymphokine-activated killer T-cell-originated protein kinase at cysteines 70 and 70. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

53

PDB code

Structure name

crystal structure of pdz-binding kinase

Structure deposition date

2016-03-28

Thiol separation (Å)

8

Half-sphere exposure sum ?

40

Minimum pK_a ?

9

% buried

0

Peptide A name

Lymphokine-activated killer T-cell-originated protein kinase

Peptide B name

Lymphokine-activated killer T-cell-originated protein kinase

Peptide A accession

Peptide B accession

Peptide A residue number

70

Peptide B residue number

70

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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