a tool for identifying drug-targetable redox-active disulphides

DnaJ homolog subfamily C member 1

Intramolecular

Cysteine 526 and cysteine 535

A redox-regulated disulphide may form within DnaJ homolog subfamily C member 1 between cysteines 526 and 535 (50 and 59 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

47

PDB code

Structure name

solution structure of rsgi ruh-043, a myb dna-binding domain in human cdna

Structure deposition date

2005-05-20

Thiol separation (Å)

9

Half-sphere exposure sum ?

65

Minimum pK_a ?

9

% buried

20

Peptide accession

Residue number A

526

Residue number B

535

Peptide name

DnaJ homolog subfamily C member 1

Ligandability

Cysteine 526 of DnaJ homolog subfamily C member 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 535 of DnaJ homolog subfamily C member 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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