ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Exocyst complex component 2

Intramolecular
Cysteine 48 and cysteine 62
Cysteine 44 and cysteine 48
Cysteine 44 and cysteine 62
A redox-regulated disulphide may form within Exocyst complex component 2 between cysteines 48 and 62.

Details

Redox score ?
73
PDB code
1uad
Structure name
crystal structure of the rala-gppnhp-sec5 ral-binding domain complex
Structure deposition date
2003-03-09
Thiol separation (Å)
4
Half-sphere exposure sum ?
66
Minimum pKa ?
7
% buried
66
Peptide accession
O54921
Residue number A
48
Residue number B
62
Peptide name
Exocyst complex component 2

Ligandability

Cysteine 48 of Exocyst complex component 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 62 of Exocyst complex component 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Exocyst complex component 2 between cysteines 44 and 48. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
1hk6
Structure name
ral binding domain from sec5
Structure deposition date
2003-03-05
Thiol separation (Å)
8
Half-sphere exposure sum ?
57
Minimum pKa ?
10
% buried
30
Peptide accession
Q9D4H1
Residue number A
44
Residue number B
48
Peptide name
Exocyst complex component 2

Ligandability

Cysteine 44 of Exocyst complex component 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 48 of Exocyst complex component 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Exocyst complex component 2 between cysteines 44 and 62. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
1hk6
Structure name
ral binding domain from sec5
Structure deposition date
2003-03-05
Thiol separation (Å)
10
Half-sphere exposure sum ?
59
Minimum pKa ?
10
% buried
51
Peptide accession
Q9D4H1
Residue number A
44
Residue number B
62
Peptide name
Exocyst complex component 2

Ligandability

Cysteine 44 of Exocyst complex component 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 62 of Exocyst complex component 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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