ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Cytosolic non-specific dipeptidase

Intramolecular
Cysteine 95 and cysteine 161
Cysteine 95 and cysteine 192 L
A redox-regulated disulphide may form within Cytosolic non-specific dipeptidase between cysteines 95 and 161. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
4ruh
Structure name
crystal structure of human carnosinase-2 (cn2) in complex with inhibitor, bestatin at 2
Structure deposition date
2014-11-19
Thiol separation (Å)
6
Half-sphere exposure sum ?
87
Minimum pKa ?
13
% buried
100
Peptide accession
Q96KP4
Residue number A
95
Residue number B
161
Peptide name
Cytosolic non-specific dipeptidase

Ligandability

Cysteine 95 of Cytosolic non-specific dipeptidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 161 of Cytosolic non-specific dipeptidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cytosolic non-specific dipeptidase between cysteines 95 and 192. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
25
PDB code
4ruh
Structure name
crystal structure of human carnosinase-2 (cn2) in complex with inhibitor, bestatin at 2
Structure deposition date
2014-11-19
Thiol separation (Å)
10
Half-sphere exposure sum ?
86
Minimum pKa ?
13
% buried
100
Peptide accession
Q96KP4
Residue number A
95
Residue number B
192
Peptide name
Cytosolic non-specific dipeptidase

Ligandability

Cysteine 95 of Cytosolic non-specific dipeptidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 192 of Cytosolic non-specific dipeptidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

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