ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Sorting nexin-27

Intramolecular
Cysteine 432 and cysteine 434 L
Cysteine 432 and cysteine 456 L
Cysteine 193 and cysteine 247
Cysteine 434 and cysteine 487 L
A redox-regulated disulphide may form within Sorting nexin-27 between cysteines 432 and 434. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
7ct1
Structure name
crystal structure of snx27 ferm domain in complex with a dlf motif
Structure deposition date
2020-08-17
Thiol separation (Å)
7
Half-sphere exposure sum ?
66
Minimum pKa ?
11
% buried
70
Peptide accession
Q96L92
Residue number A
432
Residue number B
434
Peptide name
Sorting nexin-27

Ligandability

Cysteine 432 of Sorting nexin-27

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 434 of Sorting nexin-27

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sorting nexin-27 between cysteines 432 and 456. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
7ct1
Structure name
crystal structure of snx27 ferm domain in complex with a dlf motif
Structure deposition date
2020-08-17
Thiol separation (Å)
8
Half-sphere exposure sum ?
60
Minimum pKa ?
10
% buried
46
Peptide accession
Q96L92
Residue number A
432
Residue number B
456
Peptide name
Sorting nexin-27

Ligandability

Cysteine 432 of Sorting nexin-27

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 456 of Sorting nexin-27

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sorting nexin-27 between cysteines 193 and 247 (202 and 256 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
4has
Structure name
crystal structure of px domain of human sorting nexin snx27
Structure deposition date
2012-09-27
Thiol separation (Å)
10
Half-sphere exposure sum ?
56
Minimum pKa ?
11
% buried
66
Peptide accession
Q96L92
Residue number A
193
Residue number B
247
Peptide name
Sorting nexin-27

Ligandability

Cysteine 193 of Sorting nexin-27

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 247 of Sorting nexin-27

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sorting nexin-27 between cysteines 434 and 487. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
7ct1
Structure name
crystal structure of snx27 ferm domain in complex with a dlf motif
Structure deposition date
2020-08-17
Thiol separation (Å)
10
Half-sphere exposure sum ?
63
Minimum pKa ?
11
% buried
50
Peptide accession
Q96L92
Residue number A
434
Residue number B
487
Peptide name
Sorting nexin-27

Ligandability

Cysteine 434 of Sorting nexin-27

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 487 of Sorting nexin-27

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

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