ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Mas-related G-protein coupled receptor member X4

Intramolecular
Cysteine 161 and cysteine 173
Cysteine 188 and cysteine 192
A redox-regulated disulphide may form within Mas-related G-protein coupled receptor member X4 between cysteines 161 and 173.

Details

Redox score ?
89
PDB code
7s8p
Structure name
cryoem structure of gq-coupled mrgprx4 with small molecule agonist ms47134
Structure deposition date
2021-09-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
31
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96LA9
Residue number A
161
Residue number B
173
Peptide name
Mas-related G-protein coupled receptor member X4

Ligandability

Cysteine 161 of Mas-related G-protein coupled receptor member X4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 173 of Mas-related G-protein coupled receptor member X4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mas-related G-protein coupled receptor member X4 between cysteines 188 and 192.

Details

Redox score ?
71
PDB code
7s8p
Structure name
cryoem structure of gq-coupled mrgprx4 with small molecule agonist ms47134
Structure deposition date
2021-09-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
55
Minimum pKa ?
9
% buried
15
Peptide accession
Q96LA9
Residue number A
188
Residue number B
192
Peptide name
Mas-related G-protein coupled receptor member X4

Ligandability

Cysteine 188 of Mas-related G-protein coupled receptor member X4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 192 of Mas-related G-protein coupled receptor member X4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: