ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Guanine nucleotide exchange factor C9orf72

Intramolecular
Cysteine 233 and cysteine 321
Cysteine 262 and cysteine 266
Cysteine 231 and cysteine 321
Cysteine 233 and cysteine 252
Cysteine 233 and cysteine 262
Cysteine 231 and cysteine 233
Cysteine 131 and cysteine 262
A redox-regulated disulphide may form within Guanine nucleotide exchange factor C9orf72 between cysteines 233 and 321.

Details

Redox score ?
68
PDB code
7mge
Structure name
structure of c9orf72:smcr8:wdr41 in complex with arf1
Structure deposition date
2021-04-12
Thiol separation (Å)
5
Half-sphere exposure sum ?
nan
Minimum pKa ?
10
% buried
36
Peptide accession
Q96LT7
Residue number A
233
Residue number B
321
Peptide name
Guanine nucleotide exchange factor C9orf72

Ligandability

Cysteine 233 of Guanine nucleotide exchange factor C9orf72

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 321 of Guanine nucleotide exchange factor C9orf72

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Guanine nucleotide exchange factor C9orf72 between cysteines 262 and 266.

Details

Redox score ?
67
PDB code
6v4u
Structure name
cryo-em structure of smcr8-c9orf72-wdr41 complex
Structure deposition date
2019-12-01
Thiol separation (Å)
6
Half-sphere exposure sum ?
nan
Minimum pKa ?
8
% buried
21
Peptide accession
Q96LT7
Residue number A
262
Residue number B
266
Peptide name
Guanine nucleotide exchange factor C9orf72

Ligandability

Cysteine 262 of Guanine nucleotide exchange factor C9orf72

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 266 of Guanine nucleotide exchange factor C9orf72

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Guanine nucleotide exchange factor C9orf72 between cysteines 231 and 321. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
7o2w
Structure name
structure of the c9orf72-smcr8 complex
Structure deposition date
2021-03-31
Thiol separation (Å)
6
Half-sphere exposure sum ?
81
Minimum pKa ?
12
% buried
89
Peptide accession
Q96LT7
Residue number A
231
Residue number B
321
Peptide name
Guanine nucleotide exchange factor C9orf72

Ligandability

Cysteine 231 of Guanine nucleotide exchange factor C9orf72

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 321 of Guanine nucleotide exchange factor C9orf72

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Guanine nucleotide exchange factor C9orf72 between cysteines 233 and 252. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
7o2w
Structure name
structure of the c9orf72-smcr8 complex
Structure deposition date
2021-03-31
Thiol separation (Å)
6
Half-sphere exposure sum ?
92
Minimum pKa ?
12
% buried
100
Peptide accession
Q96LT7
Residue number A
233
Residue number B
252
Peptide name
Guanine nucleotide exchange factor C9orf72

Ligandability

Cysteine 233 of Guanine nucleotide exchange factor C9orf72

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 252 of Guanine nucleotide exchange factor C9orf72

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Guanine nucleotide exchange factor C9orf72 between cysteines 233 and 262. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
7mge
Structure name
structure of c9orf72:smcr8:wdr41 in complex with arf1
Structure deposition date
2021-04-12
Thiol separation (Å)
8
Half-sphere exposure sum ?
80
Minimum pKa ?
10
% buried
56
Peptide accession
Q96LT7
Residue number A
233
Residue number B
262
Peptide name
Guanine nucleotide exchange factor C9orf72

Ligandability

Cysteine 233 of Guanine nucleotide exchange factor C9orf72

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 262 of Guanine nucleotide exchange factor C9orf72

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Guanine nucleotide exchange factor C9orf72 between cysteines 231 and 233. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
6lt0
Structure name
cryo-em structure of c9orf72-smcr8-wdr41
Structure deposition date
2020-01-21
Thiol separation (Å)
7
Half-sphere exposure sum ?
85
Minimum pKa ?
12
% buried
100
Peptide accession
Q96LT7
Residue number A
231
Residue number B
233
Peptide name
Guanine nucleotide exchange factor C9orf72

Ligandability

Cysteine 231 of Guanine nucleotide exchange factor C9orf72

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 233 of Guanine nucleotide exchange factor C9orf72

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Guanine nucleotide exchange factor C9orf72 between cysteines 131 and 262. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
7mge
Structure name
structure of c9orf72:smcr8:wdr41 in complex with arf1
Structure deposition date
2021-04-12
Thiol separation (Å)
10
Half-sphere exposure sum ?
73
Minimum pKa ?
10
% buried
63
Peptide accession
Q96LT7
Residue number A
131
Residue number B
262
Peptide name
Guanine nucleotide exchange factor C9orf72

Ligandability

Cysteine 131 of Guanine nucleotide exchange factor C9orf72

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 262 of Guanine nucleotide exchange factor C9orf72

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: