ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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DNA-directed primase/polymerase protein

Intramolecular
Cysteine 139 and cysteine 150
A redox-regulated disulphide may form within DNA-directed primase/polymerase protein between cysteines 139 and 150.

Details

Redox score ?
80
PDB code
7jl8
Structure name
human primpol extending from the correct primer base c opposite the 8- oxoguanine lesion
Structure deposition date
2020-07-29
Thiol separation (Å)
3
Half-sphere exposure sum ?
55
Minimum pKa ?
7
% buried
52
Peptide accession
Q96LW4
Residue number A
139
Residue number B
150
Peptide name
DNA-directed primase/polymerase protein

Ligandability

Cysteine 139 of DNA-directed primase/polymerase protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 150 of DNA-directed primase/polymerase protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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