ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Zinc finger protein 512

Intramolecular
Cysteine 199 and cysteine 202
Cysteine 171 and cysteine 174
Cysteine 171 and cysteine 192
Cysteine 174 and cysteine 192
A redox-regulated disulphide may form within Zinc finger protein 512 between cysteines 199 and 202 (65 and 68 respectively in this structure).

Details

Redox score ?
93
PDB code
2ctd
Structure name
solution structure of two zf-c2h2 domains from human zinc finger protein 512
Structure deposition date
2005-05-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
34
Minimum pKa ?
4
% buried
0
Peptide accession
Q96ME7
Residue number A
199
Residue number B
202
Peptide name
Zinc finger protein 512

Ligandability

Cysteine 199 of Zinc finger protein 512

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 202 of Zinc finger protein 512

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Zinc finger protein 512 between cysteines 171 and 174 (37 and 40 respectively in this structure).

Details

Redox score ?
91
PDB code
2ctd
Structure name
solution structure of two zf-c2h2 domains from human zinc finger protein 512
Structure deposition date
2005-05-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
47
Minimum pKa ?
5
% buried
1
Peptide accession
Q96ME7
Residue number A
171
Residue number B
174
Peptide name
Zinc finger protein 512

Ligandability

Cysteine 171 of Zinc finger protein 512

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 174 of Zinc finger protein 512

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Zinc finger protein 512 between cysteines 171 and 192 (37 and 58 respectively in this structure).

Details

Redox score ?
89
PDB code
2ctd
Structure name
solution structure of two zf-c2h2 domains from human zinc finger protein 512
Structure deposition date
2005-05-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
49
Minimum pKa ?
5
% buried
1
Peptide accession
Q96ME7
Residue number A
171
Residue number B
192
Peptide name
Zinc finger protein 512

Ligandability

Cysteine 171 of Zinc finger protein 512

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 192 of Zinc finger protein 512

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Zinc finger protein 512 between cysteines 174 and 192 (40 and 58 respectively in this structure).

Details

Redox score ?
83
PDB code
2ctd
Structure name
solution structure of two zf-c2h2 domains from human zinc finger protein 512
Structure deposition date
2005-05-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
38
Minimum pKa ?
8
% buried
0
Peptide accession
Q96ME7
Residue number A
174
Residue number B
192
Peptide name
Zinc finger protein 512

Ligandability

Cysteine 174 of Zinc finger protein 512

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 192 of Zinc finger protein 512

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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