ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Pseudokinase FAM20A

Intramolecular
Cysteine 211 and cysteine 323
Cysteine 209 and cysteine 319
Cysteine 314 and cysteine 330
Cysteine 453 and cysteine 512
Cysteine 378 and cysteine 452
Cysteine 209 and cysteine 323
Cysteine 319 and cysteine 323
Cysteine 209 and cysteine 211
Cysteine 211 and cysteine 319
Cysteine 378 and cysteine 453
More...
Cysteine 452 and cysteine 453
Cysteine 452 and cysteine 512
Cysteine 378 and cysteine 512
A redox-regulated disulphide may form within Pseudokinase FAM20A between cysteines 211 and 323.

Details

Redox score ?
85
PDB code
5wrr
Structure name
crystal structure of fam20a
Structure deposition date
2016-12-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96MK3
Residue number A
211
Residue number B
323
Peptide name
Pseudokinase FAM20A

Ligandability

Cysteine 211 of Pseudokinase FAM20A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 323 of Pseudokinase FAM20A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pseudokinase FAM20A between cysteines 209 and 319.

Details

Redox score ?
83
PDB code
5wrr
Structure name
crystal structure of fam20a
Structure deposition date
2016-12-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96MK3
Residue number A
209
Residue number B
319
Peptide name
Pseudokinase FAM20A

Ligandability

Cysteine 209 of Pseudokinase FAM20A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 319 of Pseudokinase FAM20A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pseudokinase FAM20A between cysteines 314 and 330.

Details

Redox score ?
82
PDB code
5wrr
Structure name
crystal structure of fam20a
Structure deposition date
2016-12-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96MK3
Residue number A
314
Residue number B
330
Peptide name
Pseudokinase FAM20A

Ligandability

Cysteine 314 of Pseudokinase FAM20A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 330 of Pseudokinase FAM20A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pseudokinase FAM20A between cysteines 453 and 512.

Details

Redox score ?
82
PDB code
5wrr
Structure name
crystal structure of fam20a
Structure deposition date
2016-12-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96MK3
Residue number A
453
Residue number B
512
Peptide name
Pseudokinase FAM20A

Ligandability

Cysteine 453 of Pseudokinase FAM20A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 512 of Pseudokinase FAM20A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pseudokinase FAM20A between cysteines 378 and 452.

Details

Redox score ?
82
PDB code
5wrr
Structure name
crystal structure of fam20a
Structure deposition date
2016-12-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96MK3
Residue number A
378
Residue number B
452
Peptide name
Pseudokinase FAM20A

Ligandability

Cysteine 378 of Pseudokinase FAM20A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 452 of Pseudokinase FAM20A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pseudokinase FAM20A between cysteines 209 and 323.

Details

Redox score ?
72
PDB code
5wrs
Structure name
crystal structure of fam20a in complex with atp
Structure deposition date
2016-12-03
Thiol separation (Å)
4
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96MK3
Residue number A
209
Residue number B
323
Peptide name
Pseudokinase FAM20A

Ligandability

Cysteine 209 of Pseudokinase FAM20A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 323 of Pseudokinase FAM20A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pseudokinase FAM20A between cysteines 319 and 323.

Details

Redox score ?
70
PDB code
5wrs
Structure name
crystal structure of fam20a in complex with atp
Structure deposition date
2016-12-03
Thiol separation (Å)
4
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96MK3
Residue number A
319
Residue number B
323
Peptide name
Pseudokinase FAM20A

Ligandability

Cysteine 319 of Pseudokinase FAM20A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 323 of Pseudokinase FAM20A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pseudokinase FAM20A between cysteines 209 and 211.

Details

Redox score ?
67
PDB code
5wrr
Structure name
crystal structure of fam20a
Structure deposition date
2016-12-03
Thiol separation (Å)
5
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96MK3
Residue number A
209
Residue number B
211
Peptide name
Pseudokinase FAM20A

Ligandability

Cysteine 209 of Pseudokinase FAM20A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 211 of Pseudokinase FAM20A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pseudokinase FAM20A between cysteines 211 and 319.

Details

Redox score ?
63
PDB code
5wrr
Structure name
crystal structure of fam20a
Structure deposition date
2016-12-03
Thiol separation (Å)
6
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96MK3
Residue number A
211
Residue number B
319
Peptide name
Pseudokinase FAM20A

Ligandability

Cysteine 211 of Pseudokinase FAM20A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 319 of Pseudokinase FAM20A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pseudokinase FAM20A between cysteines 378 and 453. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
5wrs
Structure name
crystal structure of fam20a in complex with atp
Structure deposition date
2016-12-03
Thiol separation (Å)
9
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96MK3
Residue number A
378
Residue number B
453
Peptide name
Pseudokinase FAM20A

Ligandability

Cysteine 378 of Pseudokinase FAM20A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 453 of Pseudokinase FAM20A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pseudokinase FAM20A between cysteines 452 and 453. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
5wrs
Structure name
crystal structure of fam20a in complex with atp
Structure deposition date
2016-12-03
Thiol separation (Å)
8
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96MK3
Residue number A
452
Residue number B
453
Peptide name
Pseudokinase FAM20A

Ligandability

Cysteine 452 of Pseudokinase FAM20A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 453 of Pseudokinase FAM20A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pseudokinase FAM20A between cysteines 452 and 512. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
5wrr
Structure name
crystal structure of fam20a
Structure deposition date
2016-12-03
Thiol separation (Å)
9
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96MK3
Residue number A
452
Residue number B
512
Peptide name
Pseudokinase FAM20A

Ligandability

Cysteine 452 of Pseudokinase FAM20A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 512 of Pseudokinase FAM20A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pseudokinase FAM20A between cysteines 378 and 512. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
5wrr
Structure name
crystal structure of fam20a
Structure deposition date
2016-12-03
Thiol separation (Å)
10
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96MK3
Residue number A
378
Residue number B
512
Peptide name
Pseudokinase FAM20A

Ligandability

Cysteine 378 of Pseudokinase FAM20A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 512 of Pseudokinase FAM20A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: