ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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YTH domain-containing protein 1

Intramolecular
Cysteine 449 and cysteine 489
Cysteine 484 and cysteine 489
A redox-regulated disulphide may form within YTH domain-containing protein 1 between cysteines 449 and 489. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
7p87
Structure name
crystal structure of ythdc1 with compound yli_dc1_001
Structure deposition date
2021-07-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
76
Minimum pKa ?
11
% buried
78
Peptide accession
Q96MU7
Residue number A
449
Residue number B
489
Peptide name
YTH domain-containing protein 1

Ligandability

Cysteine 449 of YTH domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 489 of YTH domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within YTH domain-containing protein 1 between cysteines 484 and 489. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
6wea
Structure name
yth domain of human ythdc1 with a 10mer oligo containing n6ma
Structure deposition date
2020-04-01
Thiol separation (Å)
10
Half-sphere exposure sum ?
78
Minimum pKa ?
11
% buried
77
Peptide accession
Q96MU7
Residue number A
484
Residue number B
489
Peptide name
YTH domain-containing protein 1

Ligandability

Cysteine 484 of YTH domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 489 of YTH domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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