ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Dynein axonemal assembly factor 10

Intramolecular
Cysteine 337 and cysteine 339
Cysteine 24 and cysteine 339
Cysteine 24 and cysteine 337
Cysteine 167 and cysteine 184 L
A redox-regulated disulphide may form within Dynein axonemal assembly factor 10 between cysteines 337 and 339. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
3i2n
Structure name
crystal structure of wd40 repeats protein wdr92
Structure deposition date
2009-06-29
Thiol separation (Å)
6
Half-sphere exposure sum ?
90
Minimum pKa ?
12
% buried
100
Peptide accession
Q96MX6
Residue number A
337
Residue number B
339
Peptide name
Dynein axonemal assembly factor 10

Ligandability

Cysteine 337 of Dynein axonemal assembly factor 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 339 of Dynein axonemal assembly factor 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Dynein axonemal assembly factor 10 between cysteines 24 and 339. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
3i2n
Structure name
crystal structure of wd40 repeats protein wdr92
Structure deposition date
2009-06-29
Thiol separation (Å)
7
Half-sphere exposure sum ?
93
Minimum pKa ?
12
% buried
100
Peptide accession
Q96MX6
Residue number A
24
Residue number B
339
Peptide name
Dynein axonemal assembly factor 10

Ligandability

Cysteine 24 of Dynein axonemal assembly factor 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 339 of Dynein axonemal assembly factor 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Dynein axonemal assembly factor 10 between cysteines 24 and 337. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
3i2n
Structure name
crystal structure of wd40 repeats protein wdr92
Structure deposition date
2009-06-29
Thiol separation (Å)
8
Half-sphere exposure sum ?
82
Minimum pKa ?
13
% buried
100
Peptide accession
Q96MX6
Residue number A
24
Residue number B
337
Peptide name
Dynein axonemal assembly factor 10

Ligandability

Cysteine 24 of Dynein axonemal assembly factor 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 337 of Dynein axonemal assembly factor 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Dynein axonemal assembly factor 10 between cysteines 167 and 184. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
26
PDB code
3i2n
Structure name
crystal structure of wd40 repeats protein wdr92
Structure deposition date
2009-06-29
Thiol separation (Å)
10
Half-sphere exposure sum ?
88
Minimum pKa ?
12
% buried
100
Peptide accession
Q96MX6
Residue number A
167
Residue number B
184
Peptide name
Dynein axonemal assembly factor 10

Ligandability

Cysteine 167 of Dynein axonemal assembly factor 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 184 of Dynein axonemal assembly factor 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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