Leucine-rich repeat and fibronectin type-III domain-containing protein 5
Intramolecular
Cysteine 20 and cysteine 26
Cysteine 246 and cysteine 284
Cysteine 24 and cysteine 37
Cysteine 244 and cysteine 263
Cysteine 308 and cysteine 357
Cysteine 20 and cysteine 24
Cysteine 24 and cysteine 26
Cysteine 26 and cysteine 37
Cysteine 20 and cysteine 37
6f2o A 20 A 26
A redox-regulated disulphide may form within Leucine-rich repeat and fibronectin type-III domain-containing protein 5 between cysteines 20 and 26.
Details
Redox score ?
89
PDB code
6f2o
Structure name
crystal structure of mouse salm5 adhesion protein extracellular lrr-ig domain fragment
Structure deposition date
2017-11-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8BXA0
Residue number A
20
Residue number B
26
Peptide name
Leucine-rich repeat and fibronectin type-III domain-containing protein 5
Ligandability
Cysteine 20 of Leucine-rich repeat and fibronectin type-III domain-containing protein 5
Cysteine 26 of Leucine-rich repeat and fibronectin type-III domain-containing protein 5
5xnq A 246 A 284
A redox-regulated disulphide may form within Leucine-rich repeat and fibronectin type-III domain-containing protein 5 between cysteines 246 and 284.
Details
Redox score ?
86
PDB code
5xnq
Structure name
crystal structures of human salm5
Structure deposition date
2017-05-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96NI6
Residue number A
246
Residue number B
284
Peptide name
Leucine-rich repeat and fibronectin type-III domain-containing protein 5
Ligandability
Cysteine 246 of Leucine-rich repeat and fibronectin type-III domain-containing protein 5
Cysteine 284 of Leucine-rich repeat and fibronectin type-III domain-containing protein 5
5xnp B 24 B 37
A redox-regulated disulphide may form within Leucine-rich repeat and fibronectin type-III domain-containing protein 5 between cysteines 24 and 37.
Details
Redox score ?
85
PDB code
5xnp
Structure name
crystal structures of human salm5 in complex with human ptpdelta
Structure deposition date
2017-05-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96NI6
Residue number A
24
Residue number B
37
Peptide name
Leucine-rich repeat and fibronectin type-III domain-containing protein 5
Ligandability
Cysteine 24 of Leucine-rich repeat and fibronectin type-III domain-containing protein 5
Cysteine 37 of Leucine-rich repeat and fibronectin type-III domain-containing protein 5
5xnp B 244 B 263
A redox-regulated disulphide may form within Leucine-rich repeat and fibronectin type-III domain-containing protein 5 between cysteines 244 and 263.
Details
Redox score ?
81
PDB code
5xnp
Structure name
crystal structures of human salm5 in complex with human ptpdelta
Structure deposition date
2017-05-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96NI6
Residue number A
244
Residue number B
263
Peptide name
Leucine-rich repeat and fibronectin type-III domain-containing protein 5
Ligandability
Cysteine 244 of Leucine-rich repeat and fibronectin type-III domain-containing protein 5
Cysteine 263 of Leucine-rich repeat and fibronectin type-III domain-containing protein 5
5xnp B 308 B 357
A redox-regulated disulphide may form within Leucine-rich repeat and fibronectin type-III domain-containing protein 5 between cysteines 308 and 357.
Details
Redox score ?
80
PDB code
5xnp
Structure name
crystal structures of human salm5 in complex with human ptpdelta
Structure deposition date
2017-05-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96NI6
Residue number A
308
Residue number B
357
Peptide name
Leucine-rich repeat and fibronectin type-III domain-containing protein 5
Ligandability
Cysteine 308 of Leucine-rich repeat and fibronectin type-III domain-containing protein 5
Cysteine 357 of Leucine-rich repeat and fibronectin type-III domain-containing protein 5
6f2o A 20 A 24
A redox-regulated disulphide may form within Leucine-rich repeat and fibronectin type-III domain-containing protein 5 between cysteines 20 and 24.
Details
Redox score ?
66
PDB code
6f2o
Structure name
crystal structure of mouse salm5 adhesion protein extracellular lrr-ig domain fragment
Structure deposition date
2017-11-25
Thiol separation (Å)
6
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8BXA0
Residue number A
20
Residue number B
24
Peptide name
Leucine-rich repeat and fibronectin type-III domain-containing protein 5
Ligandability
Cysteine 20 of Leucine-rich repeat and fibronectin type-III domain-containing protein 5
Cysteine 24 of Leucine-rich repeat and fibronectin type-III domain-containing protein 5
5xnp A 24 A 26
A redox-regulated disulphide may form within Leucine-rich repeat and fibronectin type-III domain-containing protein 5 between cysteines 24 and 26.
Details
Redox score ?
63
PDB code
5xnp
Structure name
crystal structures of human salm5 in complex with human ptpdelta
Structure deposition date
2017-05-24
Thiol separation (Å)
6
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96NI6
Residue number A
24
Residue number B
26
Peptide name
Leucine-rich repeat and fibronectin type-III domain-containing protein 5
Ligandability
Cysteine 24 of Leucine-rich repeat and fibronectin type-III domain-containing protein 5
Cysteine 26 of Leucine-rich repeat and fibronectin type-III domain-containing protein 5
5xnq A 26 A 37
A redox-regulated disulphide may form within Leucine-rich repeat and fibronectin type-III domain-containing protein 5 between cysteines 26 and 37. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
58
PDB code
5xnq
Structure name
crystal structures of human salm5
Structure deposition date
2017-05-24
Thiol separation (Å)
7
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96NI6
Residue number A
26
Residue number B
37
Peptide name
Leucine-rich repeat and fibronectin type-III domain-containing protein 5
Ligandability
Cysteine 26 of Leucine-rich repeat and fibronectin type-III domain-containing protein 5
Cysteine 37 of Leucine-rich repeat and fibronectin type-III domain-containing protein 5
6f2o A 20 A 37
A redox-regulated disulphide may form within Leucine-rich repeat and fibronectin type-III domain-containing protein 5 between cysteines 20 and 37. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
57
PDB code
6f2o
Structure name
crystal structure of mouse salm5 adhesion protein extracellular lrr-ig domain fragment
Structure deposition date
2017-11-25
Thiol separation (Å)
7
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8BXA0
Residue number A
20
Residue number B
37
Peptide name
Leucine-rich repeat and fibronectin type-III domain-containing protein 5
Ligandability
Cysteine 20 of Leucine-rich repeat and fibronectin type-III domain-containing protein 5
Cysteine 37 of Leucine-rich repeat and fibronectin type-III domain-containing protein 5
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