ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Nectin-4

Intramolecular
Cysteine 171 and cysteine 223
Cysteine 52 and cysteine 127
A redox-regulated disulphide may form within Nectin-4 between cysteines 171 and 223.

Details

Redox score ?
82
PDB code
4frw
Structure name
crystal structure of human nectin-4 extracellular fragment d1-d2
Structure deposition date
2012-06-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96NY8
Residue number A
171
Residue number B
223
Peptide name
Nectin-4

Ligandability

Cysteine 171 of Nectin-4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 223 of Nectin-4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Nectin-4 between cysteines 52 and 127.

Details

Redox score ?
81
PDB code
4frw
Structure name
crystal structure of human nectin-4 extracellular fragment d1-d2
Structure deposition date
2012-06-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96NY8
Residue number A
52
Residue number B
127
Peptide name
Nectin-4

Ligandability

Cysteine 52 of Nectin-4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 127 of Nectin-4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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