ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Baculoviral IAP repeat-containing protein 8

Intramolecular
Cysteine 39 and cysteine 66
Cysteine 42 and cysteine 66
Cysteine 39 and cysteine 42
A redox-regulated disulphide may form within Baculoviral IAP repeat-containing protein 8 between cysteines 39 and 66 (300 and 327 respectively in this structure).

Details

Redox score ?
76
PDB code
1xb1
Structure name
the structure of the bir domain of iap-like protein 2
Structure deposition date
2004-08-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
84
Minimum pKa ?
6
% buried
nan
Peptide accession
Q96P09
Residue number A
39
Residue number B
66
Peptide name
Baculoviral IAP repeat-containing protein 8

Ligandability

Cysteine 39 of Baculoviral IAP repeat-containing protein 8

Cysteine 66 of Baculoviral IAP repeat-containing protein 8

A redox-regulated disulphide may form within Baculoviral IAP repeat-containing protein 8 between cysteines 42 and 66 (303 and 327 respectively in this structure).

Details

Redox score ?
76
PDB code
1xb0
Structure name
structure of the bir domain of iap-like protein 2
Structure deposition date
2004-08-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
77
Minimum pKa ?
6
% buried
98
Peptide accession
Q96P09
Residue number A
42
Residue number B
66
Peptide name
Baculoviral IAP repeat-containing protein 8

Ligandability

Cysteine 42 of Baculoviral IAP repeat-containing protein 8

Cysteine 66 of Baculoviral IAP repeat-containing protein 8

A redox-regulated disulphide may form within Baculoviral IAP repeat-containing protein 8 between cysteines 39 and 42 (300 and 303 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
1xb0
Structure name
structure of the bir domain of iap-like protein 2
Structure deposition date
2004-08-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
82
Minimum pKa ?
18
% buried
nan
Peptide accession
Q96P09
Residue number A
39
Residue number B
42
Peptide name
Baculoviral IAP repeat-containing protein 8

Ligandability

Cysteine 39 of Baculoviral IAP repeat-containing protein 8

Cysteine 42 of Baculoviral IAP repeat-containing protein 8

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