ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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28S rRNA (cytosine-C(5))-methyltransferase

Intramolecular
Cysteine 308 and cysteine 359
Cysteine 278 and cysteine 279
Cysteine 308 and cysteine 362
A redox-regulated disulphide may form within 28S rRNA (cytosine-C(5))-methyltransferase between cysteines 308 and 359.

Details

Redox score ?
83
PDB code
2b9e
Structure name
human nsun5 protein
Structure deposition date
2005-10-11
Thiol separation (Å)
3
Half-sphere exposure sum ?
63
Minimum pKa ?
7
% buried
64
Peptide accession
Q9NW70
Residue number A
308
Residue number B
359
Peptide name
28S rRNA (cytosine-C(5))-methyltransferase

Ligandability

Cysteine 308 of 28S rRNA (cytosine-C(5))-methyltransferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 359 of 28S rRNA (cytosine-C(5))-methyltransferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within 28S rRNA (cytosine-C(5))-methyltransferase between cysteines 278 and 279. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
2b9e
Structure name
human nsun5 protein
Structure deposition date
2005-10-11
Thiol separation (Å)
7
Half-sphere exposure sum ?
69
Minimum pKa ?
11
% buried
72
Peptide accession
Q9NW70
Residue number A
278
Residue number B
279
Peptide name
28S rRNA (cytosine-C(5))-methyltransferase

Ligandability

Cysteine 278 of 28S rRNA (cytosine-C(5))-methyltransferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 279 of 28S rRNA (cytosine-C(5))-methyltransferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within 28S rRNA (cytosine-C(5))-methyltransferase between cysteines 308 and 362. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
2b9e
Structure name
human nsun5 protein
Structure deposition date
2005-10-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
59
Minimum pKa ?
9
% buried
37
Peptide accession
Q9NW70
Residue number A
308
Residue number B
362
Peptide name
28S rRNA (cytosine-C(5))-methyltransferase

Ligandability

Cysteine 308 of 28S rRNA (cytosine-C(5))-methyltransferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 362 of 28S rRNA (cytosine-C(5))-methyltransferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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