ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Importin-9

Intramolecular
Cysteine 667 and cysteine 700
Cysteine 588 and cysteine 591
Cysteine 591 and cysteine 639 L
Cysteine 606 and cysteine 639 L
Cysteine 545 and cysteine 591
Cysteine 700 and cysteine 716
A redox-regulated disulphide may form within Importin-9 between cysteines 667 and 700.

Details

Redox score ?
75
PDB code
6n1z
Structure name
importin-9 bound to h2a-h2b
Structure deposition date
2018-11-12
Thiol separation (Å)
3
Half-sphere exposure sum ?
81
Minimum pKa ?
7
% buried
62
Peptide accession
Q96P70
Residue number A
667
Residue number B
700
Peptide name
Importin-9

Ligandability

Cysteine 667 of Importin-9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 700 of Importin-9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Importin-9 between cysteines 588 and 591. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
6n1z
Structure name
importin-9 bound to h2a-h2b
Structure deposition date
2018-11-12
Thiol separation (Å)
6
Half-sphere exposure sum ?
78
Minimum pKa ?
12
% buried
86
Peptide accession
Q96P70
Residue number A
588
Residue number B
591
Peptide name
Importin-9

Ligandability

Cysteine 588 of Importin-9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 591 of Importin-9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Importin-9 between cysteines 591 and 639. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
6n1z
Structure name
importin-9 bound to h2a-h2b
Structure deposition date
2018-11-12
Thiol separation (Å)
8
Half-sphere exposure sum ?
73
Minimum pKa ?
11
% buried
74
Peptide accession
Q96P70
Residue number A
591
Residue number B
639
Peptide name
Importin-9

Ligandability

Cysteine 591 of Importin-9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 639 of Importin-9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Importin-9 between cysteines 606 and 639. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
6n1z
Structure name
importin-9 bound to h2a-h2b
Structure deposition date
2018-11-12
Thiol separation (Å)
9
Half-sphere exposure sum ?
71
Minimum pKa ?
11
% buried
60
Peptide accession
Q96P70
Residue number A
606
Residue number B
639
Peptide name
Importin-9

Ligandability

Cysteine 606 of Importin-9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 639 of Importin-9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Importin-9 between cysteines 545 and 591. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
30
PDB code
6n1z
Structure name
importin-9 bound to h2a-h2b
Structure deposition date
2018-11-12
Thiol separation (Å)
10
Half-sphere exposure sum ?
76
Minimum pKa ?
12
% buried
98
Peptide accession
Q96P70
Residue number A
545
Residue number B
591
Peptide name
Importin-9

Ligandability

Cysteine 545 of Importin-9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 591 of Importin-9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Importin-9 between cysteines 700 and 716. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
27
PDB code
6n1z
Structure name
importin-9 bound to h2a-h2b
Structure deposition date
2018-11-12
Thiol separation (Å)
10
Half-sphere exposure sum ?
78
Minimum pKa ?
12
% buried
81
Peptide accession
Q96P70
Residue number A
700
Residue number B
716
Peptide name
Importin-9

Ligandability

Cysteine 700 of Importin-9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 716 of Importin-9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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