ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

RING finger and CHY zinc finger domain-containing protein 1

Intramolecular
Cysteine 222 and cysteine 240
Cysteine 119 and cysteine 136
Cysteine 240 and cysteine 243
Cysteine 225 and cysteine 240
Cysteine 102 and cysteine 105
Cysteine 75 and cysteine 78
Cysteine 183 and cysteine 186
Cysteine 164 and cysteine 183
Cysteine 102 and cysteine 125
Cysteine 122 and cysteine 136
More...
Cysteine 65 and cysteine 78
Cysteine 33 and cysteine 34
Cysteine 119 and cysteine 122
Cysteine 62 and cysteine 78
Cysteine 164 and cysteine 186
Cysteine 222 and cysteine 225
Cysteine 87 and cysteine 108
Cysteine 145 and cysteine 172
Cysteine 145 and cysteine 148
Cysteine 87 and cysteine 90
Cysteine 20 and cysteine 43
Cysteine 62 and cysteine 75
Cysteine 225 and cysteine 243
Cysteine 65 and cysteine 75
Cysteine 105 and cysteine 125
Cysteine 222 and cysteine 243
Cysteine 20 and cysteine 40
Cysteine 148 and cysteine 172
Cysteine 90 and cysteine 108
Cysteine 62 and cysteine 65
Cysteine 40 and cysteine 43
Cysteine 27 and cysteine 75
Cysteine 102 and cysteine 119
Cysteine 105 and cysteine 119
Cysteine 145 and cysteine 183
Cysteine 119 and cysteine 125
Cysteine 27 and cysteine 78
Cysteine 102 and cysteine 108
Cysteine 105 and cysteine 122
Cysteine 90 and cysteine 102
A redox-regulated disulphide may form within RING finger and CHY zinc finger domain-containing protein 1 between cysteines 222 and 240 (40 and 58 respectively in this structure).

Details

Redox score ?
90
PDB code
2k2d
Structure name
solution nmr structure of c-terminal domain of human pirh2
Structure deposition date
2008-03-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
53
Minimum pKa ?
6
% buried
0
Peptide accession
Q96PM5
Residue number A
222
Residue number B
240
Peptide name
RING finger and CHY zinc finger domain-containing protein 1

Ligandability

Cysteine 222 of RING finger and CHY zinc finger domain-containing protein 1

Cysteine 240 of RING finger and CHY zinc finger domain-containing protein 1

A redox-regulated disulphide may form within RING finger and CHY zinc finger domain-containing protein 1 between cysteines 119 and 136 (118 and 135 respectively in this structure).

Details

Redox score ?
88
PDB code
2dkt
Structure name
solution structure of the chy zinc finger domain of the ring finger and chy zinc finger domain-containing protein 1 from mus musculus
Structure deposition date
2006-04-14
Thiol separation (Å)
4
Half-sphere exposure sum ?
41
Minimum pKa ?
6
% buried
0
Peptide accession
Q9CR50
Residue number A
119
Residue number B
136
Peptide name
RING finger and CHY zinc finger domain-containing protein 1

Ligandability

Cysteine 119 of RING finger and CHY zinc finger domain-containing protein 1

Cysteine 136 of RING finger and CHY zinc finger domain-containing protein 1

A redox-regulated disulphide may form within RING finger and CHY zinc finger domain-containing protein 1 between cysteines 240 and 243 (58 and 61 respectively in this structure).

Details

Redox score ?
88
PDB code
2k2d
Structure name
solution nmr structure of c-terminal domain of human pirh2
Structure deposition date
2008-03-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
46
Minimum pKa ?
6
% buried
0
Peptide accession
Q96PM5
Residue number A
240
Residue number B
243
Peptide name
RING finger and CHY zinc finger domain-containing protein 1

Ligandability

Cysteine 240 of RING finger and CHY zinc finger domain-containing protein 1

Cysteine 243 of RING finger and CHY zinc finger domain-containing protein 1

A redox-regulated disulphide may form within RING finger and CHY zinc finger domain-containing protein 1 between cysteines 225 and 240 (43 and 58 respectively in this structure).

Details

Redox score ?
88
PDB code
2k2d
Structure name
solution nmr structure of c-terminal domain of human pirh2
Structure deposition date
2008-03-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
47
Minimum pKa ?
6
% buried
0
Peptide accession
Q96PM5
Residue number A
225
Residue number B
240
Peptide name
RING finger and CHY zinc finger domain-containing protein 1

Ligandability

Cysteine 225 of RING finger and CHY zinc finger domain-containing protein 1

Cysteine 240 of RING finger and CHY zinc finger domain-containing protein 1

A redox-regulated disulphide may form within RING finger and CHY zinc finger domain-containing protein 1 between cysteines 102 and 105.

Details

Redox score ?
87
PDB code
2k2c
Structure name
solution nmr structure of n-terminal domain of human pirh2
Structure deposition date
2008-03-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
45
Minimum pKa ?
7
% buried
2
Peptide accession
Q96PM5
Residue number A
102
Residue number B
105
Peptide name
RING finger and CHY zinc finger domain-containing protein 1

Ligandability

Cysteine 102 of RING finger and CHY zinc finger domain-containing protein 1

Cysteine 105 of RING finger and CHY zinc finger domain-containing protein 1

A redox-regulated disulphide may form within RING finger and CHY zinc finger domain-containing protein 1 between cysteines 75 and 78.

Details

Redox score ?
86
PDB code
2k2c
Structure name
solution nmr structure of n-terminal domain of human pirh2
Structure deposition date
2008-03-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
45
Minimum pKa ?
6
% buried
0
Peptide accession
Q96PM5
Residue number A
75
Residue number B
78
Peptide name
RING finger and CHY zinc finger domain-containing protein 1

Ligandability

Cysteine 75 of RING finger and CHY zinc finger domain-containing protein 1

Cysteine 78 of RING finger and CHY zinc finger domain-containing protein 1

A redox-regulated disulphide may form within RING finger and CHY zinc finger domain-containing protein 1 between cysteines 183 and 186 (55 and 58 respectively in this structure).

Details

Redox score ?
86
PDB code
2jrj
Structure name
solution structure of the human pirh2 ring-h2 domain
Structure deposition date
2007-06-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
36
Minimum pKa ?
7
% buried
0
Peptide accession
Q86X26
Residue number A
183
Residue number B
186
Peptide name
RING finger and CHY zinc finger domain-containing protein 1

Ligandability

Cysteine 183 of RING finger and CHY zinc finger domain-containing protein 1

Cysteine 186 of RING finger and CHY zinc finger domain-containing protein 1

A redox-regulated disulphide may form within RING finger and CHY zinc finger domain-containing protein 1 between cysteines 164 and 183 (36 and 55 respectively in this structure).

Details

Redox score ?
85
PDB code
2jrj
Structure name
solution structure of the human pirh2 ring-h2 domain
Structure deposition date
2007-06-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
36
Minimum pKa ?
7
% buried
0
Peptide accession
Q86X26
Residue number A
164
Residue number B
183
Peptide name
RING finger and CHY zinc finger domain-containing protein 1

Ligandability

Cysteine 164 of RING finger and CHY zinc finger domain-containing protein 1

Cysteine 183 of RING finger and CHY zinc finger domain-containing protein 1

A redox-regulated disulphide may form within RING finger and CHY zinc finger domain-containing protein 1 between cysteines 102 and 125.

Details

Redox score ?
84
PDB code
2k2c
Structure name
solution nmr structure of n-terminal domain of human pirh2
Structure deposition date
2008-03-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
59
Minimum pKa ?
7
% buried
6
Peptide accession
Q96PM5
Residue number A
102
Residue number B
125
Peptide name
RING finger and CHY zinc finger domain-containing protein 1

Ligandability

Cysteine 102 of RING finger and CHY zinc finger domain-containing protein 1

Cysteine 125 of RING finger and CHY zinc finger domain-containing protein 1

A redox-regulated disulphide may form within RING finger and CHY zinc finger domain-containing protein 1 between cysteines 122 and 136.

Details

Redox score ?
84
PDB code
2k2c
Structure name
solution nmr structure of n-terminal domain of human pirh2
Structure deposition date
2008-03-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
28
Minimum pKa ?
9
% buried
0
Peptide accession
Q96PM5
Residue number A
122
Residue number B
136
Peptide name
RING finger and CHY zinc finger domain-containing protein 1

Ligandability

Cysteine 122 of RING finger and CHY zinc finger domain-containing protein 1

Cysteine 136 of RING finger and CHY zinc finger domain-containing protein 1

A redox-regulated disulphide may form within RING finger and CHY zinc finger domain-containing protein 1 between cysteines 65 and 78.

Details

Redox score ?
83
PDB code
2k2c
Structure name
solution nmr structure of n-terminal domain of human pirh2
Structure deposition date
2008-03-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
37
Minimum pKa ?
6
% buried
0
Peptide accession
Q96PM5
Residue number A
65
Residue number B
78
Peptide name
RING finger and CHY zinc finger domain-containing protein 1

Ligandability

Cysteine 65 of RING finger and CHY zinc finger domain-containing protein 1

Cysteine 78 of RING finger and CHY zinc finger domain-containing protein 1

A redox-regulated disulphide may form within RING finger and CHY zinc finger domain-containing protein 1 between cysteines 33 and 34 (32 and 33 respectively in this structure).

Details

Redox score ?
82
PDB code
2dkt
Structure name
solution structure of the chy zinc finger domain of the ring finger and chy zinc finger domain-containing protein 1 from mus musculus
Structure deposition date
2006-04-14
Thiol separation (Å)
4
Half-sphere exposure sum ?
39
Minimum pKa ?
8
% buried
0
Peptide accession
Q9CR50
Residue number A
33
Residue number B
34
Peptide name
RING finger and CHY zinc finger domain-containing protein 1

Ligandability

Cysteine 33 of RING finger and CHY zinc finger domain-containing protein 1

Cysteine 34 of RING finger and CHY zinc finger domain-containing protein 1

A redox-regulated disulphide may form within RING finger and CHY zinc finger domain-containing protein 1 between cysteines 119 and 122.

Details

Redox score ?
82
PDB code
2k2c
Structure name
solution nmr structure of n-terminal domain of human pirh2
Structure deposition date
2008-03-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
40
Minimum pKa ?
9
% buried
0
Peptide accession
Q96PM5
Residue number A
119
Residue number B
122
Peptide name
RING finger and CHY zinc finger domain-containing protein 1

Ligandability

Cysteine 119 of RING finger and CHY zinc finger domain-containing protein 1

Cysteine 122 of RING finger and CHY zinc finger domain-containing protein 1

A redox-regulated disulphide may form within RING finger and CHY zinc finger domain-containing protein 1 between cysteines 62 and 78.

Details

Redox score ?
82
PDB code
2k2c
Structure name
solution nmr structure of n-terminal domain of human pirh2
Structure deposition date
2008-03-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
55
Minimum pKa ?
6
% buried
8
Peptide accession
Q96PM5
Residue number A
62
Residue number B
78
Peptide name
RING finger and CHY zinc finger domain-containing protein 1

Ligandability

Cysteine 62 of RING finger and CHY zinc finger domain-containing protein 1

Cysteine 78 of RING finger and CHY zinc finger domain-containing protein 1

A redox-regulated disulphide may form within RING finger and CHY zinc finger domain-containing protein 1 between cysteines 164 and 186 (36 and 58 respectively in this structure).

Details

Redox score ?
82
PDB code
2jrj
Structure name
solution structure of the human pirh2 ring-h2 domain
Structure deposition date
2007-06-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
28
Minimum pKa ?
9
% buried
0
Peptide accession
Q86X26
Residue number A
164
Residue number B
186
Peptide name
RING finger and CHY zinc finger domain-containing protein 1

Ligandability

Cysteine 164 of RING finger and CHY zinc finger domain-containing protein 1

Cysteine 186 of RING finger and CHY zinc finger domain-containing protein 1

A redox-regulated disulphide may form within RING finger and CHY zinc finger domain-containing protein 1 between cysteines 222 and 225 (40 and 43 respectively in this structure).

Details

Redox score ?
81
PDB code
2k2d
Structure name
solution nmr structure of c-terminal domain of human pirh2
Structure deposition date
2008-03-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
44
Minimum pKa ?
9
% buried
0
Peptide accession
Q96PM5
Residue number A
222
Residue number B
225
Peptide name
RING finger and CHY zinc finger domain-containing protein 1

Ligandability

Cysteine 222 of RING finger and CHY zinc finger domain-containing protein 1

Cysteine 225 of RING finger and CHY zinc finger domain-containing protein 1

A redox-regulated disulphide may form within RING finger and CHY zinc finger domain-containing protein 1 between cysteines 87 and 108.

Details

Redox score ?
81
PDB code
2k2c
Structure name
solution nmr structure of n-terminal domain of human pirh2
Structure deposition date
2008-03-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
57
Minimum pKa ?
7
% buried
34
Peptide accession
Q96PM5
Residue number A
87
Residue number B
108
Peptide name
RING finger and CHY zinc finger domain-containing protein 1

Ligandability

Cysteine 87 of RING finger and CHY zinc finger domain-containing protein 1

Cysteine 108 of RING finger and CHY zinc finger domain-containing protein 1

A redox-regulated disulphide may form within RING finger and CHY zinc finger domain-containing protein 1 between cysteines 145 and 172 (17 and 44 respectively in this structure).

Details

Redox score ?
80
PDB code
2jrj
Structure name
solution structure of the human pirh2 ring-h2 domain
Structure deposition date
2007-06-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
54
Minimum pKa ?
8
% buried
19
Peptide accession
Q86X26
Residue number A
145
Residue number B
172
Peptide name
RING finger and CHY zinc finger domain-containing protein 1

Ligandability

Cysteine 145 of RING finger and CHY zinc finger domain-containing protein 1

Cysteine 172 of RING finger and CHY zinc finger domain-containing protein 1

A redox-regulated disulphide may form within RING finger and CHY zinc finger domain-containing protein 1 between cysteines 145 and 148 (17 and 20 respectively in this structure).

Details

Redox score ?
80
PDB code
2jrj
Structure name
solution structure of the human pirh2 ring-h2 domain
Structure deposition date
2007-06-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
44
Minimum pKa ?
8
% buried
14
Peptide accession
Q86X26
Residue number A
145
Residue number B
148
Peptide name
RING finger and CHY zinc finger domain-containing protein 1

Ligandability

Cysteine 145 of RING finger and CHY zinc finger domain-containing protein 1

Cysteine 148 of RING finger and CHY zinc finger domain-containing protein 1

A redox-regulated disulphide may form within RING finger and CHY zinc finger domain-containing protein 1 between cysteines 87 and 90.

Details

Redox score ?
80
PDB code
2k2c
Structure name
solution nmr structure of n-terminal domain of human pirh2
Structure deposition date
2008-03-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
54
Minimum pKa ?
7
% buried
28
Peptide accession
Q96PM5
Residue number A
87
Residue number B
90
Peptide name
RING finger and CHY zinc finger domain-containing protein 1

Ligandability

Cysteine 87 of RING finger and CHY zinc finger domain-containing protein 1

Cysteine 90 of RING finger and CHY zinc finger domain-containing protein 1

A redox-regulated disulphide may form within RING finger and CHY zinc finger domain-containing protein 1 between cysteines 20 and 43.

Details

Redox score ?
80
PDB code
2k2c
Structure name
solution nmr structure of n-terminal domain of human pirh2
Structure deposition date
2008-03-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
47
Minimum pKa ?
8
% buried
11
Peptide accession
Q96PM5
Residue number A
20
Residue number B
43
Peptide name
RING finger and CHY zinc finger domain-containing protein 1

Ligandability

Cysteine 20 of RING finger and CHY zinc finger domain-containing protein 1

Cysteine 43 of RING finger and CHY zinc finger domain-containing protein 1

A redox-regulated disulphide may form within RING finger and CHY zinc finger domain-containing protein 1 between cysteines 62 and 75.

Details

Redox score ?
79
PDB code
2k2c
Structure name
solution nmr structure of n-terminal domain of human pirh2
Structure deposition date
2008-03-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
65
Minimum pKa ?
9
% buried
9
Peptide accession
Q96PM5
Residue number A
62
Residue number B
75
Peptide name
RING finger and CHY zinc finger domain-containing protein 1

Ligandability

Cysteine 62 of RING finger and CHY zinc finger domain-containing protein 1

Cysteine 75 of RING finger and CHY zinc finger domain-containing protein 1

A redox-regulated disulphide may form within RING finger and CHY zinc finger domain-containing protein 1 between cysteines 225 and 243 (43 and 61 respectively in this structure).

Details

Redox score ?
79
PDB code
2k2d
Structure name
solution nmr structure of c-terminal domain of human pirh2
Structure deposition date
2008-03-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
37
Minimum pKa ?
9
% buried
0
Peptide accession
Q96PM5
Residue number A
225
Residue number B
243
Peptide name
RING finger and CHY zinc finger domain-containing protein 1

Ligandability

Cysteine 225 of RING finger and CHY zinc finger domain-containing protein 1

Cysteine 243 of RING finger and CHY zinc finger domain-containing protein 1

A redox-regulated disulphide may form within RING finger and CHY zinc finger domain-containing protein 1 between cysteines 65 and 75.

Details

Redox score ?
78
PDB code
2k2c
Structure name
solution nmr structure of n-terminal domain of human pirh2
Structure deposition date
2008-03-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
46
Minimum pKa ?
9
% buried
0
Peptide accession
Q96PM5
Residue number A
65
Residue number B
75
Peptide name
RING finger and CHY zinc finger domain-containing protein 1

Ligandability

Cysteine 65 of RING finger and CHY zinc finger domain-containing protein 1

Cysteine 75 of RING finger and CHY zinc finger domain-containing protein 1

A redox-regulated disulphide may form within RING finger and CHY zinc finger domain-containing protein 1 between cysteines 105 and 125.

Details

Redox score ?
78
PDB code
2k2c
Structure name
solution nmr structure of n-terminal domain of human pirh2
Structure deposition date
2008-03-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
54
Minimum pKa ?
10
% buried
6
Peptide accession
Q96PM5
Residue number A
105
Residue number B
125
Peptide name
RING finger and CHY zinc finger domain-containing protein 1

Ligandability

Cysteine 105 of RING finger and CHY zinc finger domain-containing protein 1

Cysteine 125 of RING finger and CHY zinc finger domain-containing protein 1

A redox-regulated disulphide may form within RING finger and CHY zinc finger domain-containing protein 1 between cysteines 222 and 243 (40 and 61 respectively in this structure).

Details

Redox score ?
77
PDB code
2k2d
Structure name
solution nmr structure of c-terminal domain of human pirh2
Structure deposition date
2008-03-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
43
Minimum pKa ?
11
% buried
0
Peptide accession
Q96PM5
Residue number A
222
Residue number B
243
Peptide name
RING finger and CHY zinc finger domain-containing protein 1

Ligandability

Cysteine 222 of RING finger and CHY zinc finger domain-containing protein 1

Cysteine 243 of RING finger and CHY zinc finger domain-containing protein 1

A redox-regulated disulphide may form within RING finger and CHY zinc finger domain-containing protein 1 between cysteines 20 and 40.

Details

Redox score ?
77
PDB code
2k2c
Structure name
solution nmr structure of n-terminal domain of human pirh2
Structure deposition date
2008-03-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
55
Minimum pKa ?
8
% buried
26
Peptide accession
Q96PM5
Residue number A
20
Residue number B
40
Peptide name
RING finger and CHY zinc finger domain-containing protein 1

Ligandability

Cysteine 20 of RING finger and CHY zinc finger domain-containing protein 1

Cysteine 40 of RING finger and CHY zinc finger domain-containing protein 1

A redox-regulated disulphide may form within RING finger and CHY zinc finger domain-containing protein 1 between cysteines 148 and 172 (20 and 44 respectively in this structure).

Details

Redox score ?
76
PDB code
2jrj
Structure name
solution structure of the human pirh2 ring-h2 domain
Structure deposition date
2007-06-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
44
Minimum pKa ?
10
% buried
6
Peptide accession
Q86X26
Residue number A
148
Residue number B
172
Peptide name
RING finger and CHY zinc finger domain-containing protein 1

Ligandability

Cysteine 148 of RING finger and CHY zinc finger domain-containing protein 1

Cysteine 172 of RING finger and CHY zinc finger domain-containing protein 1

A redox-regulated disulphide may form within RING finger and CHY zinc finger domain-containing protein 1 between cysteines 90 and 108.

Details

Redox score ?
75
PDB code
2k2c
Structure name
solution nmr structure of n-terminal domain of human pirh2
Structure deposition date
2008-03-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
58
Minimum pKa ?
10
% buried
36
Peptide accession
Q96PM5
Residue number A
90
Residue number B
108
Peptide name
RING finger and CHY zinc finger domain-containing protein 1

Ligandability

Cysteine 90 of RING finger and CHY zinc finger domain-containing protein 1

Cysteine 108 of RING finger and CHY zinc finger domain-containing protein 1

A redox-regulated disulphide may form within RING finger and CHY zinc finger domain-containing protein 1 between cysteines 62 and 65.

Details

Redox score ?
74
PDB code
2k2c
Structure name
solution nmr structure of n-terminal domain of human pirh2
Structure deposition date
2008-03-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
56
Minimum pKa ?
10
% buried
8
Peptide accession
Q96PM5
Residue number A
62
Residue number B
65
Peptide name
RING finger and CHY zinc finger domain-containing protein 1

Ligandability

Cysteine 62 of RING finger and CHY zinc finger domain-containing protein 1

Cysteine 65 of RING finger and CHY zinc finger domain-containing protein 1

A redox-regulated disulphide may form within RING finger and CHY zinc finger domain-containing protein 1 between cysteines 40 and 43.

Details

Redox score ?
72
PDB code
2k2c
Structure name
solution nmr structure of n-terminal domain of human pirh2
Structure deposition date
2008-03-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
59
Minimum pKa ?
9
% buried
27
Peptide accession
Q96PM5
Residue number A
40
Residue number B
43
Peptide name
RING finger and CHY zinc finger domain-containing protein 1

Ligandability

Cysteine 40 of RING finger and CHY zinc finger domain-containing protein 1

Cysteine 43 of RING finger and CHY zinc finger domain-containing protein 1

A redox-regulated disulphide may form within RING finger and CHY zinc finger domain-containing protein 1 between cysteines 27 and 75. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
56
PDB code
2k2c
Structure name
solution nmr structure of n-terminal domain of human pirh2
Structure deposition date
2008-03-31
Thiol separation (Å)
7
Half-sphere exposure sum ?
70
Minimum pKa ?
9
% buried
39
Peptide accession
Q96PM5
Residue number A
27
Residue number B
75
Peptide name
RING finger and CHY zinc finger domain-containing protein 1

Ligandability

Cysteine 27 of RING finger and CHY zinc finger domain-containing protein 1

Cysteine 75 of RING finger and CHY zinc finger domain-containing protein 1

A redox-regulated disulphide may form within RING finger and CHY zinc finger domain-containing protein 1 between cysteines 102 and 119. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
2k2c
Structure name
solution nmr structure of n-terminal domain of human pirh2
Structure deposition date
2008-03-31
Thiol separation (Å)
10
Half-sphere exposure sum ?
48
Minimum pKa ?
7
% buried
1
Peptide accession
Q96PM5
Residue number A
102
Residue number B
119
Peptide name
RING finger and CHY zinc finger domain-containing protein 1

Ligandability

Cysteine 102 of RING finger and CHY zinc finger domain-containing protein 1

Cysteine 119 of RING finger and CHY zinc finger domain-containing protein 1

A redox-regulated disulphide may form within RING finger and CHY zinc finger domain-containing protein 1 between cysteines 105 and 119. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
2k2c
Structure name
solution nmr structure of n-terminal domain of human pirh2
Structure deposition date
2008-03-31
Thiol separation (Å)
9
Half-sphere exposure sum ?
43
Minimum pKa ?
9
% buried
1
Peptide accession
Q96PM5
Residue number A
105
Residue number B
119
Peptide name
RING finger and CHY zinc finger domain-containing protein 1

Ligandability

Cysteine 105 of RING finger and CHY zinc finger domain-containing protein 1

Cysteine 119 of RING finger and CHY zinc finger domain-containing protein 1

A redox-regulated disulphide may form within RING finger and CHY zinc finger domain-containing protein 1 between cysteines 145 and 183 (8 and 46 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
2ecm
Structure name
solution structure of the ring domain of the ring finger and chy zinc finger domain-containing protein 1 from mus musculus
Structure deposition date
2007-02-13
Thiol separation (Å)
10
Half-sphere exposure sum ?
57
Minimum pKa ?
6
% buried
9
Peptide accession
Q9CR50
Residue number A
145
Residue number B
183
Peptide name
RING finger and CHY zinc finger domain-containing protein 1

Ligandability

Cysteine 145 of RING finger and CHY zinc finger domain-containing protein 1

Cysteine 183 of RING finger and CHY zinc finger domain-containing protein 1

A redox-regulated disulphide may form within RING finger and CHY zinc finger domain-containing protein 1 between cysteines 119 and 125. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
2k2c
Structure name
solution nmr structure of n-terminal domain of human pirh2
Structure deposition date
2008-03-31
Thiol separation (Å)
9
Half-sphere exposure sum ?
57
Minimum pKa ?
9
% buried
5
Peptide accession
Q96PM5
Residue number A
119
Residue number B
125
Peptide name
RING finger and CHY zinc finger domain-containing protein 1

Ligandability

Cysteine 119 of RING finger and CHY zinc finger domain-containing protein 1

Cysteine 125 of RING finger and CHY zinc finger domain-containing protein 1

A redox-regulated disulphide may form within RING finger and CHY zinc finger domain-containing protein 1 between cysteines 27 and 78. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
2k2c
Structure name
solution nmr structure of n-terminal domain of human pirh2
Structure deposition date
2008-03-31
Thiol separation (Å)
9
Half-sphere exposure sum ?
60
Minimum pKa ?
6
% buried
38
Peptide accession
Q96PM5
Residue number A
27
Residue number B
78
Peptide name
RING finger and CHY zinc finger domain-containing protein 1

Ligandability

Cysteine 27 of RING finger and CHY zinc finger domain-containing protein 1

Cysteine 78 of RING finger and CHY zinc finger domain-containing protein 1

A redox-regulated disulphide may form within RING finger and CHY zinc finger domain-containing protein 1 between cysteines 102 and 108. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
2k2c
Structure name
solution nmr structure of n-terminal domain of human pirh2
Structure deposition date
2008-03-31
Thiol separation (Å)
10
Half-sphere exposure sum ?
54
Minimum pKa ?
7
% buried
22
Peptide accession
Q96PM5
Residue number A
102
Residue number B
108
Peptide name
RING finger and CHY zinc finger domain-containing protein 1

Ligandability

Cysteine 102 of RING finger and CHY zinc finger domain-containing protein 1

Cysteine 108 of RING finger and CHY zinc finger domain-containing protein 1

A redox-regulated disulphide may form within RING finger and CHY zinc finger domain-containing protein 1 between cysteines 105 and 122. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
2k2c
Structure name
solution nmr structure of n-terminal domain of human pirh2
Structure deposition date
2008-03-31
Thiol separation (Å)
9
Half-sphere exposure sum ?
37
Minimum pKa ?
10
% buried
1
Peptide accession
Q96PM5
Residue number A
105
Residue number B
122
Peptide name
RING finger and CHY zinc finger domain-containing protein 1

Ligandability

Cysteine 105 of RING finger and CHY zinc finger domain-containing protein 1

Cysteine 122 of RING finger and CHY zinc finger domain-containing protein 1

A redox-regulated disulphide may form within RING finger and CHY zinc finger domain-containing protein 1 between cysteines 90 and 102. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
2k2c
Structure name
solution nmr structure of n-terminal domain of human pirh2
Structure deposition date
2008-03-31
Thiol separation (Å)
10
Half-sphere exposure sum ?
53
Minimum pKa ?
7
% buried
16
Peptide accession
Q96PM5
Residue number A
90
Residue number B
102
Peptide name
RING finger and CHY zinc finger domain-containing protein 1

Ligandability

Cysteine 90 of RING finger and CHY zinc finger domain-containing protein 1

Cysteine 102 of RING finger and CHY zinc finger domain-containing protein 1

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