ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Adenylate cyclase type 10

Intramolecular
Cysteine 193 and cysteine 197
Cysteine 346 and cysteine 365
Cysteine 342 and cysteine 373
Cysteine 346 and cysteine 373
Cysteine 365 and cysteine 373
A redox-regulated disulphide may form within Adenylate cyclase type 10 between cysteines 193 and 197.

Details

Redox score ?
79
PDB code
4cm0
Structure name
crystal structure of human soluble adenylyl cyclase with alpha,beta- methyleneadenosine-5'-triphosphate soaked with bicarbonate
Structure deposition date
2014-01-15
Thiol separation (Å)
3
Half-sphere exposure sum ?
75
Minimum pKa ?
8
% buried
94
Peptide accession
Q96PN6
Residue number A
193
Residue number B
197
Peptide name
Adenylate cyclase type 10

Ligandability

Cysteine 193 of Adenylate cyclase type 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 197 of Adenylate cyclase type 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Adenylate cyclase type 10 between cysteines 346 and 365. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
7ovd
Structure name
human soluble adenylyl cyclase in complex with the inhibitor tdi10229
Structure deposition date
2021-06-14
Thiol separation (Å)
7
Half-sphere exposure sum ?
81
Minimum pKa ?
13
% buried
92
Peptide accession
Q96PN6
Residue number A
346
Residue number B
365
Peptide name
Adenylate cyclase type 10

Ligandability

Cysteine 346 of Adenylate cyclase type 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 365 of Adenylate cyclase type 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Adenylate cyclase type 10 between cysteines 342 and 373. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
5d0r
Structure name
crystal structure of human soluble adenylyl cyclase with the inhibitor bithionol
Structure deposition date
2015-08-03
Thiol separation (Å)
10
Half-sphere exposure sum ?
78
Minimum pKa ?
12
% buried
91
Peptide accession
Q96PN6
Residue number A
342
Residue number B
373
Peptide name
Adenylate cyclase type 10

Ligandability

Cysteine 342 of Adenylate cyclase type 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 373 of Adenylate cyclase type 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Adenylate cyclase type 10 between cysteines 346 and 373. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
30
PDB code
4cll
Structure name
crystal structure of human soluble adenylyl cyclase in complex with bicarbonate
Structure deposition date
2014-01-15
Thiol separation (Å)
10
Half-sphere exposure sum ?
78
Minimum pKa ?
12
% buried
92
Peptide accession
Q96PN6
Residue number A
346
Residue number B
373
Peptide name
Adenylate cyclase type 10

Ligandability

Cysteine 346 of Adenylate cyclase type 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 373 of Adenylate cyclase type 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Adenylate cyclase type 10 between cysteines 365 and 373. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
27
PDB code
4clt
Structure name
crystal structure of human soluble adenylyl cyclase with adenosine-3', 5'-cyclic-monophosphate and pyrophosphate
Structure deposition date
2014-01-15
Thiol separation (Å)
10
Half-sphere exposure sum ?
78
Minimum pKa ?
12
% buried
84
Peptide accession
Q96PN6
Residue number A
365
Residue number B
373
Peptide name
Adenylate cyclase type 10

Ligandability

Cysteine 365 of Adenylate cyclase type 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 373 of Adenylate cyclase type 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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