ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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VPS10 domain-containing receptor SorCS2

Intramolecular
Cysteine 324 and cysteine 329
Cysteine 701 and cysteine 760
Cysteine 740 and cysteine 775
Cysteine 494 and cysteine 499
Cysteine 649 and cysteine 684
Cysteine 667 and cysteine 699
Cysteine 708 and cysteine 725
Cysteine 699 and cysteine 760
Cysteine 699 and cysteine 701
Cysteine 667 and cysteine 760
A redox-regulated disulphide may form within VPS10 domain-containing receptor SorCS2 between cysteines 324 and 329.

Details

Redox score ?
89
PDB code
6ffy
Structure name
structure of the mouse sorcs2-ngf complex
Structure deposition date
2018-01-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9EPR5
Residue number A
324
Residue number B
329
Peptide name
VPS10 domain-containing receptor SorCS2

Ligandability

Cysteine 324 of VPS10 domain-containing receptor SorCS2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 329 of VPS10 domain-containing receptor SorCS2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within VPS10 domain-containing receptor SorCS2 between cysteines 701 and 760.

Details

Redox score ?
88
PDB code
6fg9
Structure name
mouse sorcs2 ectodomain (sortilin related vps10 domain containing receptor 2)
Structure deposition date
2018-01-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9EPR5
Residue number A
701
Residue number B
760
Peptide name
VPS10 domain-containing receptor SorCS2

Ligandability

Cysteine 701 of VPS10 domain-containing receptor SorCS2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 760 of VPS10 domain-containing receptor SorCS2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within VPS10 domain-containing receptor SorCS2 between cysteines 740 and 775.

Details

Redox score ?
87
PDB code
6fg9
Structure name
mouse sorcs2 ectodomain (sortilin related vps10 domain containing receptor 2)
Structure deposition date
2018-01-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
47
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9EPR5
Residue number A
740
Residue number B
775
Peptide name
VPS10 domain-containing receptor SorCS2

Ligandability

Cysteine 740 of VPS10 domain-containing receptor SorCS2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 775 of VPS10 domain-containing receptor SorCS2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within VPS10 domain-containing receptor SorCS2 between cysteines 494 and 499.

Details

Redox score ?
86
PDB code
6fg9
Structure name
mouse sorcs2 ectodomain (sortilin related vps10 domain containing receptor 2)
Structure deposition date
2018-01-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
46
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9EPR5
Residue number A
494
Residue number B
499
Peptide name
VPS10 domain-containing receptor SorCS2

Ligandability

Cysteine 494 of VPS10 domain-containing receptor SorCS2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 499 of VPS10 domain-containing receptor SorCS2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within VPS10 domain-containing receptor SorCS2 between cysteines 649 and 684.

Details

Redox score ?
85
PDB code
6ffy
Structure name
structure of the mouse sorcs2-ngf complex
Structure deposition date
2018-01-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9EPR5
Residue number A
649
Residue number B
684
Peptide name
VPS10 domain-containing receptor SorCS2

Ligandability

Cysteine 649 of VPS10 domain-containing receptor SorCS2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 684 of VPS10 domain-containing receptor SorCS2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within VPS10 domain-containing receptor SorCS2 between cysteines 667 and 699.

Details

Redox score ?
85
PDB code
6ffy
Structure name
structure of the mouse sorcs2-ngf complex
Structure deposition date
2018-01-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9EPR5
Residue number A
667
Residue number B
699
Peptide name
VPS10 domain-containing receptor SorCS2

Ligandability

Cysteine 667 of VPS10 domain-containing receptor SorCS2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 699 of VPS10 domain-containing receptor SorCS2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within VPS10 domain-containing receptor SorCS2 between cysteines 708 and 725.

Details

Redox score ?
81
PDB code
6fg9
Structure name
mouse sorcs2 ectodomain (sortilin related vps10 domain containing receptor 2)
Structure deposition date
2018-01-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9EPR5
Residue number A
708
Residue number B
725
Peptide name
VPS10 domain-containing receptor SorCS2

Ligandability

Cysteine 708 of VPS10 domain-containing receptor SorCS2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 725 of VPS10 domain-containing receptor SorCS2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within VPS10 domain-containing receptor SorCS2 between cysteines 699 and 760. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
6fg9
Structure name
mouse sorcs2 ectodomain (sortilin related vps10 domain containing receptor 2)
Structure deposition date
2018-01-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9EPR5
Residue number A
699
Residue number B
760
Peptide name
VPS10 domain-containing receptor SorCS2

Ligandability

Cysteine 699 of VPS10 domain-containing receptor SorCS2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 760 of VPS10 domain-containing receptor SorCS2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within VPS10 domain-containing receptor SorCS2 between cysteines 699 and 701. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
6fg9
Structure name
mouse sorcs2 ectodomain (sortilin related vps10 domain containing receptor 2)
Structure deposition date
2018-01-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
48
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9EPR5
Residue number A
699
Residue number B
701
Peptide name
VPS10 domain-containing receptor SorCS2

Ligandability

Cysteine 699 of VPS10 domain-containing receptor SorCS2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 701 of VPS10 domain-containing receptor SorCS2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within VPS10 domain-containing receptor SorCS2 between cysteines 667 and 760. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
6fg9
Structure name
mouse sorcs2 ectodomain (sortilin related vps10 domain containing receptor 2)
Structure deposition date
2018-01-10
Thiol separation (Å)
10
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9EPR5
Residue number A
667
Residue number B
760
Peptide name
VPS10 domain-containing receptor SorCS2

Ligandability

Cysteine 667 of VPS10 domain-containing receptor SorCS2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 760 of VPS10 domain-containing receptor SorCS2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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