a tool for identifying drug-targetable redox-active disulphides

E3 ubiquitin-protein ligase NEDD4-like

Intermolecular

Cysteine 194 of 14-3-3 protein gamma and cysteine 341

A redox-regulated disulphide may form between cysteine 194 of 14-3-3 protein gamma and cysteine 341 of E3 ubiquitin-protein ligase NEDD4-like. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

43

PDB code

Structure name

structure of 14-3-3 gamma in complex with nedd4-2 14-3-3 binding motif ser342

Structure deposition date

2020-06-09

Thiol separation (Å)

10

Half-sphere exposure sum ?

nan

Minimum pK_a ?

9

% buried

57

Peptide A name

14-3-3 protein gamma

Peptide B name

E3 ubiquitin-protein ligase NEDD4-like

Peptide A accession

Peptide B accession

Peptide A residue number

194

Peptide B residue number

341

Ligandability

Cysteine 194 of 14-3-3 protein gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 341 of E3 ubiquitin-protein ligase NEDD4-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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