a tool for identifying drug-targetable redox-active disulphides

Rho GTPase-activating protein 7

Intramolecular

Cysteine 457 and cysteine 509

A redox-regulated disulphide may form within Rho GTPase-activating protein 7 between cysteines 457 and 509 (27 and 79 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

41

PDB code

Structure name

solution structure of the sam-domain of rho-gtpase-activating protein 7

Structure deposition date

2006-04-14

Thiol separation (Å)

9

Half-sphere exposure sum ?

73

Minimum pK_a ?

10

% buried

35

Peptide accession

Residue number A

457

Residue number B

509

Peptide name

Rho GTPase-activating protein 7

Ligandability

Cysteine 457 of Rho GTPase-activating protein 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 509 of Rho GTPase-activating protein 7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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