ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Rab-3A-interacting protein

Intermolecular
Cysteine 195 and cysteine 195
Intramolecular
Cysteine 395 and cysteine 423
Cysteine 395 and cysteine 404
Cysteine 404 and cysteine 423
Cysteine 348 and cysteine 431
A redox-regulated disulphide may form between two units of Rab-3A-interacting protein at cysteines 195 and 195 (179 and 179 respectively in this structure).

Details

Redox score ?
79
PDB code
4lhx
Structure name
crystal structure of nucleotide-free rab8:rabin8
Structure deposition date
2013-07-01
Thiol separation (Å)
4
Half-sphere exposure sum ?
48
Minimum pKa ?
9
% buried
0
Peptide A name
Rab-3A-interacting protein
Peptide B name
Rab-3A-interacting protein
Peptide A accession
Q96QF0
Peptide B accession
Q96QF0
Peptide A residue number
195
Peptide B residue number
195

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Rab-3A-interacting protein between cysteines 395 and 423 (379 and 407 respectively in this structure).

Details

Redox score ?
82
PDB code
4uj3
Structure name
crystal structure of human rab11-rabin8-fip3
Structure deposition date
2015-04-08
Thiol separation (Å)
4
Half-sphere exposure sum ?
76
Minimum pKa ?
4
% buried
64
Peptide accession
Q96QF0
Residue number A
395
Residue number B
423
Peptide name
Rab-3A-interacting protein

Ligandability

Cysteine 395 of Rab-3A-interacting protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 423 of Rab-3A-interacting protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Rab-3A-interacting protein between cysteines 395 and 404 (379 and 388 respectively in this structure).

Details

Redox score ?
81
PDB code
4uj3
Structure name
crystal structure of human rab11-rabin8-fip3
Structure deposition date
2015-04-08
Thiol separation (Å)
5
Half-sphere exposure sum ?
66
Minimum pKa ?
5
% buried
49
Peptide accession
Q96QF0
Residue number A
395
Residue number B
404
Peptide name
Rab-3A-interacting protein

Ligandability

Cysteine 395 of Rab-3A-interacting protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 404 of Rab-3A-interacting protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Rab-3A-interacting protein between cysteines 404 and 423 (388 and 407 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
4uj3
Structure name
crystal structure of human rab11-rabin8-fip3
Structure deposition date
2015-04-08
Thiol separation (Å)
8
Half-sphere exposure sum ?
81
Minimum pKa ?
11
% buried
69
Peptide accession
Q96QF0
Residue number A
404
Residue number B
423
Peptide name
Rab-3A-interacting protein

Ligandability

Cysteine 404 of Rab-3A-interacting protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 423 of Rab-3A-interacting protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Rab-3A-interacting protein between cysteines 348 and 431 (332 and 415 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
4uj5
Structure name
crystal structure of human rab11-rabin8-fip3
Structure deposition date
2015-04-08
Thiol separation (Å)
10
Half-sphere exposure sum ?
77
Minimum pKa ?
12
% buried
89
Peptide accession
Q96QF0
Residue number A
348
Residue number B
431
Peptide name
Rab-3A-interacting protein

Ligandability

Cysteine 348 of Rab-3A-interacting protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 431 of Rab-3A-interacting protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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