Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

Intermolecular

A redox-regulated disulphide may form between two units of Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 at cysteines 545 and 518 (533 and 506 respectively in this structure).

Details

Redox score ?

PDB code

2i04

Structure name

x-ray crystal structure of magi-1 pdz1 bound to the c- terminal peptide of hpv18 e6

Structure deposition date

2006-08-09

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide A name

Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

Peptide B name

Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

Peptide A accession

Q6RHR9

Peptide B accession

Q6RHR9

Peptide A residue number

545

Peptide B residue number

518

Ligandability

Cysteine 545 of Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 518 of Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 at cysteines 545 and 545 (533 and 533 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?