Bile acid receptor

Intermolecular

Intramolecular

A redox-regulated disulphide may form between two units of Bile acid receptor at cysteines 446 and 446 (445 and 445 respectively in this structure).

Details

Redox score ?

PDB code

5wzx

Structure name

structural basis for a pentacyclic oleanane-type triterpenoid as a ligand of fxr

Structure deposition date

2017-01-19

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide A name

Bile acid receptor

Peptide B name

Bile acid receptor

Peptide A accession

Q96RI1

Peptide B accession

Q96RI1

Peptide A residue number

446

Peptide B residue number

446

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Bile acid receptor between cysteines 433 and 446 (419 and 432 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?