ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Tumor necrosis factor receptor superfamily member 13C

Intermolecular
Cysteine 97 of Uncharacterized protein DKFZp686I04196 and cysteine 35
Cysteine 97 of Uncharacterized protein DKFZp686I04196 and cysteine 24
Cysteine 97 of Uncharacterized protein DKFZp686I04196 and cysteine 19
Intramolecular
Cysteine 19 and cysteine 32
Cysteine 24 and cysteine 35
Cysteine 19 and cysteine 35
Cysteine 19 and cysteine 24
Cysteine 32 and cysteine 35
Cysteine 24 and cysteine 32
A redox-regulated disulphide may form between cysteine 97 of Uncharacterized protein DKFZp686I04196 and cysteine 35 of Tumor necrosis factor receptor superfamily member 13C.

Details

Redox score ?
70
PDB code
2hfg
Structure name
crystal structure of hbr3 bound to cb3s-fab
Structure deposition date
2006-06-23
Thiol separation (Å)
5
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide A name
Uncharacterized protein DKFZp686I04196
Peptide B name
Tumor necrosis factor receptor superfamily member 13C
Peptide A accession
Q6N093
Peptide B accession
Q96RJ3
Peptide A residue number
97
Peptide B residue number
35

Ligandability

Cysteine 97 of Uncharacterized protein DKFZp686I04196

Cysteine 35 of Tumor necrosis factor receptor superfamily member 13C

Cysteine 97 in protein A could not be asigned to a Uniprot residue.
A redox-regulated disulphide may form between cysteine 97 of Uncharacterized protein DKFZp686I04196 and cysteine 24 of Tumor necrosis factor receptor superfamily member 13C.

Details

Redox score ?
63
PDB code
2hfg
Structure name
crystal structure of hbr3 bound to cb3s-fab
Structure deposition date
2006-06-23
Thiol separation (Å)
5
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide A name
Uncharacterized protein DKFZp686I04196
Peptide B name
Tumor necrosis factor receptor superfamily member 13C
Peptide A accession
Q6N093
Peptide B accession
Q96RJ3
Peptide A residue number
97
Peptide B residue number
24

Ligandability

Cysteine 97 of Uncharacterized protein DKFZp686I04196

Cysteine 24 of Tumor necrosis factor receptor superfamily member 13C

Cysteine 97 in protein A could not be asigned to a Uniprot residue.
A redox-regulated disulphide may form between cysteine 97 of Uncharacterized protein DKFZp686I04196 and cysteine 19 of Tumor necrosis factor receptor superfamily member 13C. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
2hfg
Structure name
crystal structure of hbr3 bound to cb3s-fab
Structure deposition date
2006-06-23
Thiol separation (Å)
10
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide A name
Uncharacterized protein DKFZp686I04196
Peptide B name
Tumor necrosis factor receptor superfamily member 13C
Peptide A accession
Q6N093
Peptide B accession
Q96RJ3
Peptide A residue number
97
Peptide B residue number
19

Ligandability

Cysteine 97 of Uncharacterized protein DKFZp686I04196

Cysteine 19 of Tumor necrosis factor receptor superfamily member 13C

Cysteine 97 in protein A could not be asigned to a Uniprot residue.
A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 13C between cysteines 19 and 32.

Details

Redox score ?
85
PDB code
2hfg
Structure name
crystal structure of hbr3 bound to cb3s-fab
Structure deposition date
2006-06-23
Thiol separation (Å)
2
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96RJ3
Residue number A
19
Residue number B
32
Peptide name
Tumor necrosis factor receptor superfamily member 13C

Ligandability

Cysteine 19 of Tumor necrosis factor receptor superfamily member 13C

Cysteine 32 of Tumor necrosis factor receptor superfamily member 13C

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 13C between cysteines 24 and 35.

Details

Redox score ?
84
PDB code
2hfg
Structure name
crystal structure of hbr3 bound to cb3s-fab
Structure deposition date
2006-06-23
Thiol separation (Å)
2
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96RJ3
Residue number A
24
Residue number B
35
Peptide name
Tumor necrosis factor receptor superfamily member 13C

Ligandability

Cysteine 24 of Tumor necrosis factor receptor superfamily member 13C

Cysteine 35 of Tumor necrosis factor receptor superfamily member 13C

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 13C between cysteines 19 and 35.

Details

Redox score ?
60
PDB code
2hfg
Structure name
crystal structure of hbr3 bound to cb3s-fab
Structure deposition date
2006-06-23
Thiol separation (Å)
7
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96RJ3
Residue number A
19
Residue number B
35
Peptide name
Tumor necrosis factor receptor superfamily member 13C

Ligandability

Cysteine 19 of Tumor necrosis factor receptor superfamily member 13C

Cysteine 35 of Tumor necrosis factor receptor superfamily member 13C

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 13C between cysteines 19 and 24 (4 and 9 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
59
PDB code
1oqe
Structure name
crystal structure of stall-1 with baff-r
Structure deposition date
2003-03-07
Thiol separation (Å)
7
Half-sphere exposure sum ?
39
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96RJ3
Residue number A
19
Residue number B
24
Peptide name
Tumor necrosis factor receptor superfamily member 13C

Ligandability

Cysteine 19 of Tumor necrosis factor receptor superfamily member 13C

Cysteine 24 of Tumor necrosis factor receptor superfamily member 13C

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 13C between cysteines 32 and 35 (17 and 20 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
1oqe
Structure name
crystal structure of stall-1 with baff-r
Structure deposition date
2003-03-07
Thiol separation (Å)
9
Half-sphere exposure sum ?
41
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96RJ3
Residue number A
32
Residue number B
35
Peptide name
Tumor necrosis factor receptor superfamily member 13C

Ligandability

Cysteine 32 of Tumor necrosis factor receptor superfamily member 13C

Cysteine 35 of Tumor necrosis factor receptor superfamily member 13C

A redox-regulated disulphide may form within Tumor necrosis factor receptor superfamily member 13C between cysteines 24 and 32 (9 and 17 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
1oqe
Structure name
crystal structure of stall-1 with baff-r
Structure deposition date
2003-03-07
Thiol separation (Å)
8
Half-sphere exposure sum ?
47
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q96RJ3
Residue number A
24
Residue number B
32
Peptide name
Tumor necrosis factor receptor superfamily member 13C

Ligandability

Cysteine 24 of Tumor necrosis factor receptor superfamily member 13C

Cysteine 32 of Tumor necrosis factor receptor superfamily member 13C

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