ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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BRCA1-A complex subunit RAP80

Intermolecular
Cysteine 296 of BRCA1-A complex subunit Abraxas 1 and cysteine 298
A redox-regulated disulphide may form between cysteine 296 of BRCA1-A complex subunit Abraxas 1 and cysteine 298 of BRCA1-A complex subunit RAP80. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
6gvw
Structure name
crystal structure of the brca1-a complex
Structure deposition date
2018-06-21
Thiol separation (Å)
10
Half-sphere exposure sum ?
83
Minimum pKa ?
8
% buried
92
Peptide A name
BRCA1-A complex subunit Abraxas 1
Peptide B name
BRCA1-A complex subunit RAP80
Peptide A accession
Q8BPZ8
Peptide B accession
Q5U5Q9
Peptide A residue number
296
Peptide B residue number
298

Ligandability

Cysteine 296 of BRCA1-A complex subunit Abraxas 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 298 of BRCA1-A complex subunit RAP80

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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