Twinkle mtDNA helicase

Intramolecular

A redox-regulated disulphide may form within Twinkle mtDNA helicase between cysteines 511 and 551. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

7t8b

Structure name

octameric human twinkle helicase clinical variant w315l

Structure deposition date

2021-12-16

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

100

Peptide accession

Q96RR1

Residue number A

511

Residue number B

551

Peptide name

Twinkle mtDNA helicase

Ligandability

Cysteine 511 of Twinkle mtDNA helicase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.