ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Calcium/calmodulin-dependent protein kinase kinase 2

Intramolecular
Cysteine 382 and cysteine 388
A redox-regulated disulphide may form within Calcium/calmodulin-dependent protein kinase kinase 2 between cysteines 382 and 388.

Details

Redox score ?
75
PDB code
6bqq
Structure name
crystal structure of the human camkk2b in complex with bi2526
Structure deposition date
2017-11-28
Thiol separation (Å)
3
Half-sphere exposure sum ?
77
Minimum pKa ?
8
% buried
82
Peptide accession
Q96RR4
Residue number A
382
Residue number B
388
Peptide name
Calcium/calmodulin-dependent protein kinase kinase 2

Ligandability

Cysteine 382 of Calcium/calmodulin-dependent protein kinase kinase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 388 of Calcium/calmodulin-dependent protein kinase kinase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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