ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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EKC/KEOPS complex subunit TP53RK

Intermolecular
Cysteine 91 and cysteine 167 of EKC/KEOPS complex subunit TPRKB
A redox-regulated disulphide may form between cysteine 91 of EKC/KEOPS complex subunit TP53RK and cysteine 167 of EKC/KEOPS complex subunit TPRKB. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
30
PDB code
7sza
Structure name
crystal structure analysis of human prpk complex with a compound
Structure deposition date
2021-11-27
Thiol separation (Å)
9
Half-sphere exposure sum ?
86
Minimum pKa ?
11
% buried
100
Peptide A name
EKC/KEOPS complex subunit TP53RK
Peptide B name
EKC/KEOPS complex subunit TPRKB
Peptide A accession
Q96S44
Peptide B accession
Q9Y3C4
Peptide A residue number
91
Peptide B residue number
167

Ligandability

Cysteine 91 of EKC/KEOPS complex subunit TP53RK

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 167 of EKC/KEOPS complex subunit TPRKB

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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