ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Ran-binding protein 9

Intramolecular
Cysteine 283 and cysteine 292
Cysteine 284 and cysteine 292
Cysteine 707 and cysteine 719
Cysteine 263 and cysteine 292
Cysteine 283 and cysteine 284
Cysteine 212 and cysteine 284
A redox-regulated disulphide may form within Ran-binding protein 9 between cysteines 283 and 292.

Details

Redox score ?
68
PDB code
5jiu
Structure name
the crystal structure of ranbpm/9 ius-spry domain in complex with ddx- 4 peptide
Structure deposition date
2016-04-22
Thiol separation (Å)
4
Half-sphere exposure sum ?
83
Minimum pKa ?
9
% buried
100
Peptide accession
Q96S59
Residue number A
283
Residue number B
292
Peptide name
Ran-binding protein 9

Ligandability

Cysteine 283 of Ran-binding protein 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 292 of Ran-binding protein 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ran-binding protein 9 between cysteines 284 and 292. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
5ji9
Structure name
the crystal structure of ius-spry domain from ranbpm/9
Structure deposition date
2016-04-22
Thiol separation (Å)
7
Half-sphere exposure sum ?
79
Minimum pKa ?
9
% buried
99
Peptide accession
Q96S59
Residue number A
284
Residue number B
292
Peptide name
Ran-binding protein 9

Ligandability

Cysteine 284 of Ran-binding protein 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 292 of Ran-binding protein 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ran-binding protein 9 between cysteines 707 and 719. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
7nsc
Structure name
substrate receptor scaffolding module of human ctlh e3 ubiquitin ligase
Structure deposition date
2021-03-05
Thiol separation (Å)
9
Half-sphere exposure sum ?
82
Minimum pKa ?
11
% buried
60
Peptide accession
Q96S59
Residue number A
707
Residue number B
719
Peptide name
Ran-binding protein 9

Ligandability

Cysteine 707 of Ran-binding protein 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 719 of Ran-binding protein 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ran-binding protein 9 between cysteines 263 and 292. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
5ji9
Structure name
the crystal structure of ius-spry domain from ranbpm/9
Structure deposition date
2016-04-22
Thiol separation (Å)
10
Half-sphere exposure sum ?
68
Minimum pKa ?
9
% buried
65
Peptide accession
Q96S59
Residue number A
263
Residue number B
292
Peptide name
Ran-binding protein 9

Ligandability

Cysteine 263 of Ran-binding protein 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 292 of Ran-binding protein 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ran-binding protein 9 between cysteines 283 and 284. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
5ji9
Structure name
the crystal structure of ius-spry domain from ranbpm/9
Structure deposition date
2016-04-22
Thiol separation (Å)
7
Half-sphere exposure sum ?
89
Minimum pKa ?
13
% buried
99
Peptide accession
Q96S59
Residue number A
283
Residue number B
284
Peptide name
Ran-binding protein 9

Ligandability

Cysteine 283 of Ran-binding protein 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 284 of Ran-binding protein 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ran-binding protein 9 between cysteines 212 and 284. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
30
PDB code
7nsc
Structure name
substrate receptor scaffolding module of human ctlh e3 ubiquitin ligase
Structure deposition date
2021-03-05
Thiol separation (Å)
9
Half-sphere exposure sum ?
83
Minimum pKa ?
13
% buried
100
Peptide accession
Q96S59
Residue number A
212
Residue number B
284
Peptide name
Ran-binding protein 9

Ligandability

Cysteine 212 of Ran-binding protein 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 284 of Ran-binding protein 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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