a tool for identifying drug-targetable redox-active disulphides

Integrator complex subunit 14

Intermolecular

Cysteine 406 of Integrator complex subunit 13 and cysteine 310

A redox-regulated disulphide may form between cysteine 406 of Integrator complex subunit 13 and cysteine 310 of Integrator complex subunit 14. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

41

PDB code

Structure name

crystal structure of the human ints13-ints14 complex

Structure deposition date

2019-08-23

Thiol separation (Å)

8

Half-sphere exposure sum ?

77

Minimum pK_a ?

11

% buried

80

Peptide A name

Integrator complex subunit 13

Peptide B name

Integrator complex subunit 14

Peptide A accession

Peptide B accession

Peptide A residue number

406

Peptide B residue number

310

Ligandability

Cysteine 406 of Integrator complex subunit 13

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 310 of Integrator complex subunit 14

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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