ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3

Intramolecular
Cysteine 134 and cysteine 164
Cysteine 12 and cysteine 134
A redox-regulated disulphide may form within Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 between cysteines 134 and 164.

Details

Redox score ?
66
PDB code
1nur
Structure name
crystal structure of human cytosolic nmn/namn adenylyltransferase
Structure deposition date
2003-02-01
Thiol separation (Å)
4
Half-sphere exposure sum ?
79
Minimum pKa ?
9
% buried
100
Peptide accession
Q96T66
Residue number A
134
Residue number B
164
Peptide name
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3

Ligandability

Cysteine 134 of Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 164 of Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 between cysteines 12 and 134. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
23
PDB code
1nur
Structure name
crystal structure of human cytosolic nmn/namn adenylyltransferase
Structure deposition date
2003-02-01
Thiol separation (Å)
10
Half-sphere exposure sum ?
78
Minimum pKa ?
14
% buried
100
Peptide accession
Q96T66
Residue number A
12
Residue number B
134
Peptide name
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3

Ligandability

Cysteine 12 of Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 134 of Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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