ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Protein Niban 2

Intramolecular
Cysteine 154 and cysteine 173
Cysteine 190 and cysteine 194
A redox-regulated disulphide may form within Protein Niban 2 between cysteines 154 and 173.

Details

Redox score ?
65
PDB code
7ctp
Structure name
crystal structure of human fam129b/minerva/niban2
Structure deposition date
2020-08-20
Thiol separation (Å)
5
Half-sphere exposure sum ?
65
Minimum pKa ?
10
% buried
47
Peptide accession
Q96TA1
Residue number A
154
Residue number B
173
Peptide name
Protein Niban 2

Ligandability

Cysteine 154 of Protein Niban 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 173 of Protein Niban 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein Niban 2 between cysteines 190 and 194. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
7ctp
Structure name
crystal structure of human fam129b/minerva/niban2
Structure deposition date
2020-08-20
Thiol separation (Å)
6
Half-sphere exposure sum ?
70
Minimum pKa ?
10
% buried
90
Peptide accession
Q96TA1
Residue number A
190
Residue number B
194
Peptide name
Protein Niban 2

Ligandability

Cysteine 190 of Protein Niban 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 194 of Protein Niban 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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