ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Granulocyte colony-stimulating factor receptor

Intramolecular
Cysteine 26 and cysteine 52
Cysteine 167 and cysteine 218
Cysteine 248 and cysteine 295
Cysteine 266 and cysteine 309
Cysteine 131 and cysteine 142
Cysteine 177 and cysteine 186
Cysteine 46 and cysteine 101
Cysteine 142 and cysteine 177
Cysteine 142 and cysteine 186
Cysteine 131 and cysteine 177
Cysteine 131 and cysteine 186
A redox-regulated disulphide may form within Granulocyte colony-stimulating factor receptor between cysteines 26 and 52 (3 and 29 respectively in this structure).

Details

Redox score ?
89
PDB code
2d9q
Structure name
crystal structure of the human gcsf-receptor signaling complex
Structure deposition date
2005-12-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q99062
Residue number A
26
Residue number B
52
Peptide name
Granulocyte colony-stimulating factor receptor

Ligandability

Cysteine 26 of Granulocyte colony-stimulating factor receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 52 of Granulocyte colony-stimulating factor receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Granulocyte colony-stimulating factor receptor between cysteines 167 and 218 (144 and 195 respectively in this structure).

Details

Redox score ?
87
PDB code
2d9q
Structure name
crystal structure of the human gcsf-receptor signaling complex
Structure deposition date
2005-12-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q99062
Residue number A
167
Residue number B
218
Peptide name
Granulocyte colony-stimulating factor receptor

Ligandability

Cysteine 167 of Granulocyte colony-stimulating factor receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 218 of Granulocyte colony-stimulating factor receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Granulocyte colony-stimulating factor receptor between cysteines 248 and 295 (225 and 272 respectively in this structure).

Details

Redox score ?
86
PDB code
2d9q
Structure name
crystal structure of the human gcsf-receptor signaling complex
Structure deposition date
2005-12-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
41
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q99062
Residue number A
248
Residue number B
295
Peptide name
Granulocyte colony-stimulating factor receptor

Ligandability

Cysteine 248 of Granulocyte colony-stimulating factor receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 295 of Granulocyte colony-stimulating factor receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Granulocyte colony-stimulating factor receptor between cysteines 266 and 309 (243 and 286 respectively in this structure).

Details

Redox score ?
85
PDB code
2d9q
Structure name
crystal structure of the human gcsf-receptor signaling complex
Structure deposition date
2005-12-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q99062
Residue number A
266
Residue number B
309
Peptide name
Granulocyte colony-stimulating factor receptor

Ligandability

Cysteine 266 of Granulocyte colony-stimulating factor receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 309 of Granulocyte colony-stimulating factor receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Granulocyte colony-stimulating factor receptor between cysteines 131 and 142 (108 and 119 respectively in this structure).

Details

Redox score ?
83
PDB code
2d9q
Structure name
crystal structure of the human gcsf-receptor signaling complex
Structure deposition date
2005-12-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q99062
Residue number A
131
Residue number B
142
Peptide name
Granulocyte colony-stimulating factor receptor

Ligandability

Cysteine 131 of Granulocyte colony-stimulating factor receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 142 of Granulocyte colony-stimulating factor receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Granulocyte colony-stimulating factor receptor between cysteines 177 and 186 (154 and 163 respectively in this structure).

Details

Redox score ?
83
PDB code
2d9q
Structure name
crystal structure of the human gcsf-receptor signaling complex
Structure deposition date
2005-12-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q99062
Residue number A
177
Residue number B
186
Peptide name
Granulocyte colony-stimulating factor receptor

Ligandability

Cysteine 177 of Granulocyte colony-stimulating factor receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 186 of Granulocyte colony-stimulating factor receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Granulocyte colony-stimulating factor receptor between cysteines 46 and 101 (23 and 78 respectively in this structure).

Details

Redox score ?
81
PDB code
2d9q
Structure name
crystal structure of the human gcsf-receptor signaling complex
Structure deposition date
2005-12-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q99062
Residue number A
46
Residue number B
101
Peptide name
Granulocyte colony-stimulating factor receptor

Ligandability

Cysteine 46 of Granulocyte colony-stimulating factor receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 101 of Granulocyte colony-stimulating factor receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Granulocyte colony-stimulating factor receptor between cysteines 142 and 177 (119 and 154 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
2d9q
Structure name
crystal structure of the human gcsf-receptor signaling complex
Structure deposition date
2005-12-12
Thiol separation (Å)
8
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q99062
Residue number A
142
Residue number B
177
Peptide name
Granulocyte colony-stimulating factor receptor

Ligandability

Cysteine 142 of Granulocyte colony-stimulating factor receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 177 of Granulocyte colony-stimulating factor receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Granulocyte colony-stimulating factor receptor between cysteines 142 and 186 (119 and 163 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
2d9q
Structure name
crystal structure of the human gcsf-receptor signaling complex
Structure deposition date
2005-12-12
Thiol separation (Å)
8
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q99062
Residue number A
142
Residue number B
186
Peptide name
Granulocyte colony-stimulating factor receptor

Ligandability

Cysteine 142 of Granulocyte colony-stimulating factor receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 186 of Granulocyte colony-stimulating factor receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Granulocyte colony-stimulating factor receptor between cysteines 131 and 177 (108 and 154 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
2d9q
Structure name
crystal structure of the human gcsf-receptor signaling complex
Structure deposition date
2005-12-12
Thiol separation (Å)
10
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q99062
Residue number A
131
Residue number B
177
Peptide name
Granulocyte colony-stimulating factor receptor

Ligandability

Cysteine 131 of Granulocyte colony-stimulating factor receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 177 of Granulocyte colony-stimulating factor receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Granulocyte colony-stimulating factor receptor between cysteines 131 and 186 (108 and 163 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
2d9q
Structure name
crystal structure of the human gcsf-receptor signaling complex
Structure deposition date
2005-12-12
Thiol separation (Å)
10
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q99062
Residue number A
131
Residue number B
186
Peptide name
Granulocyte colony-stimulating factor receptor

Ligandability

Cysteine 131 of Granulocyte colony-stimulating factor receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 186 of Granulocyte colony-stimulating factor receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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