ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Sodium channel protein type 2 subunit alpha

Intermolecular
Cysteine 55 of Sodium channel subunit beta-2 and cysteine 910
Cysteine 55 of Sodium channel subunit beta-2 and cysteine 912
Intramolecular
Cysteine 950 and cysteine 959
Cysteine 1731 and cysteine 1746
Cysteine 912 and cysteine 918
Cysteine 1366 and cysteine 1386
Cysteine 741 and cysteine 742
Cysteine 278 and cysteine 338
Cysteine 338 and cysteine 347
Cysteine 347 and cysteine 353
More...
Cysteine 278 and cysteine 347
Cysteine 338 and cysteine 353
Cysteine 278 and cysteine 353
Cysteine 910 and cysteine 912
A redox-regulated disulphide may form between cysteine 55 of Sodium channel subunit beta-2 and cysteine 910 of Sodium channel protein type 2 subunit alpha.

Details

Redox score ?
78
PDB code
6j8e
Structure name
human nav1
Structure deposition date
2019-01-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide A name
Sodium channel subunit beta-2
Peptide B name
Sodium channel protein type 2 subunit alpha
Peptide A accession
O60939
Peptide B accession
Q99250
Peptide A residue number
55
Peptide B residue number
910

Ligandability

Cysteine 55 of Sodium channel subunit beta-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 910 of Sodium channel protein type 2 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 55 of Sodium channel subunit beta-2 and cysteine 912 of Sodium channel protein type 2 subunit alpha. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
6j8e
Structure name
human nav1
Structure deposition date
2019-01-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide A name
Sodium channel subunit beta-2
Peptide B name
Sodium channel protein type 2 subunit alpha
Peptide A accession
O60939
Peptide B accession
Q99250
Peptide A residue number
55
Peptide B residue number
912

Ligandability

Cysteine 55 of Sodium channel subunit beta-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 912 of Sodium channel protein type 2 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium channel protein type 2 subunit alpha between cysteines 950 and 959.

Details

Redox score ?
85
PDB code
6j8e
Structure name
human nav1
Structure deposition date
2019-01-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q99250
Residue number A
950
Residue number B
959
Peptide name
Sodium channel protein type 2 subunit alpha

Ligandability

Cysteine 950 of Sodium channel protein type 2 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 959 of Sodium channel protein type 2 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium channel protein type 2 subunit alpha between cysteines 1731 and 1746.

Details

Redox score ?
85
PDB code
6j8e
Structure name
human nav1
Structure deposition date
2019-01-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q99250
Residue number A
1731
Residue number B
1746
Peptide name
Sodium channel protein type 2 subunit alpha

Ligandability

Cysteine 1731 of Sodium channel protein type 2 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1746 of Sodium channel protein type 2 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium channel protein type 2 subunit alpha between cysteines 912 and 918.

Details

Redox score ?
84
PDB code
6j8e
Structure name
human nav1
Structure deposition date
2019-01-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q99250
Residue number A
912
Residue number B
918
Peptide name
Sodium channel protein type 2 subunit alpha

Ligandability

Cysteine 912 of Sodium channel protein type 2 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 918 of Sodium channel protein type 2 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium channel protein type 2 subunit alpha between cysteines 1366 and 1386.

Details

Redox score ?
83
PDB code
6j8e
Structure name
human nav1
Structure deposition date
2019-01-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q99250
Residue number A
1366
Residue number B
1386
Peptide name
Sodium channel protein type 2 subunit alpha

Ligandability

Cysteine 1366 of Sodium channel protein type 2 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1386 of Sodium channel protein type 2 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium channel protein type 2 subunit alpha between cysteines 741 and 742.

Details

Redox score ?
83
PDB code
6j8e
Structure name
human nav1
Structure deposition date
2019-01-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
18
Minimum pKa ?
8
% buried
0
Peptide accession
Q99250
Residue number A
741
Residue number B
742
Peptide name
Sodium channel protein type 2 subunit alpha

Ligandability

Cysteine 741 of Sodium channel protein type 2 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 742 of Sodium channel protein type 2 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium channel protein type 2 subunit alpha between cysteines 278 and 338.

Details

Redox score ?
79
PDB code
6j8e
Structure name
human nav1
Structure deposition date
2019-01-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q99250
Residue number A
278
Residue number B
338
Peptide name
Sodium channel protein type 2 subunit alpha

Ligandability

Cysteine 278 of Sodium channel protein type 2 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 338 of Sodium channel protein type 2 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium channel protein type 2 subunit alpha between cysteines 338 and 347.

Details

Redox score ?
66
PDB code
6j8e
Structure name
human nav1
Structure deposition date
2019-01-18
Thiol separation (Å)
5
Half-sphere exposure sum ?
70
Minimum pKa ?
10
% buried
nan
Peptide accession
Q99250
Residue number A
338
Residue number B
347
Peptide name
Sodium channel protein type 2 subunit alpha

Ligandability

Cysteine 338 of Sodium channel protein type 2 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 347 of Sodium channel protein type 2 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium channel protein type 2 subunit alpha between cysteines 347 and 353.

Details

Redox score ?
63
PDB code
6j8e
Structure name
human nav1
Structure deposition date
2019-01-18
Thiol separation (Å)
6
Half-sphere exposure sum ?
66
Minimum pKa ?
10
% buried
35
Peptide accession
Q99250
Residue number A
347
Residue number B
353
Peptide name
Sodium channel protein type 2 subunit alpha

Ligandability

Cysteine 347 of Sodium channel protein type 2 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 353 of Sodium channel protein type 2 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium channel protein type 2 subunit alpha between cysteines 278 and 347.

Details

Redox score ?
61
PDB code
6j8e
Structure name
human nav1
Structure deposition date
2019-01-18
Thiol separation (Å)
6
Half-sphere exposure sum ?
68
Minimum pKa ?
10
% buried
nan
Peptide accession
Q99250
Residue number A
278
Residue number B
347
Peptide name
Sodium channel protein type 2 subunit alpha

Ligandability

Cysteine 278 of Sodium channel protein type 2 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 347 of Sodium channel protein type 2 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium channel protein type 2 subunit alpha between cysteines 338 and 353. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
56
PDB code
6j8e
Structure name
human nav1
Structure deposition date
2019-01-18
Thiol separation (Å)
6
Half-sphere exposure sum ?
74
Minimum pKa ?
11
% buried
nan
Peptide accession
Q99250
Residue number A
338
Residue number B
353
Peptide name
Sodium channel protein type 2 subunit alpha

Ligandability

Cysteine 338 of Sodium channel protein type 2 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 353 of Sodium channel protein type 2 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium channel protein type 2 subunit alpha between cysteines 278 and 353. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
6j8e
Structure name
human nav1
Structure deposition date
2019-01-18
Thiol separation (Å)
7
Half-sphere exposure sum ?
73
Minimum pKa ?
11
% buried
nan
Peptide accession
Q99250
Residue number A
278
Residue number B
353
Peptide name
Sodium channel protein type 2 subunit alpha

Ligandability

Cysteine 278 of Sodium channel protein type 2 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 353 of Sodium channel protein type 2 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium channel protein type 2 subunit alpha between cysteines 910 and 912. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
6j8e
Structure name
human nav1
Structure deposition date
2019-01-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q99250
Residue number A
910
Residue number B
912
Peptide name
Sodium channel protein type 2 subunit alpha

Ligandability

Cysteine 910 of Sodium channel protein type 2 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 912 of Sodium channel protein type 2 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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