ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Proteasome subunit beta type-7

Intermolecular
Cysteine 74 and cysteine 129 of Proteasome subunit beta type-3
Cysteine 247 and cysteine 150 of Proteasome subunit beta type-3
Intramolecular
Cysteine 86 and cysteine 87
Cysteine 87 and cysteine 219
Cysteine 86 and cysteine 219
A redox-regulated disulphide may form between cysteine 74 of Proteasome subunit beta type-7 and cysteine 129 of Proteasome subunit beta type-3 (31 and 128 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
3unb
Structure name
mouse constitutive 20s proteasome in complex with pr-957
Structure deposition date
2011-11-15
Thiol separation (Å)
6
Half-sphere exposure sum ?
72
Minimum pKa ?
14
% buried
100
Peptide A name
Proteasome subunit beta type-7
Peptide B name
Proteasome subunit beta type-3
Peptide A accession
P70195
Peptide B accession
Q9R1P1
Peptide A residue number
74
Peptide B residue number
129

Ligandability

Cysteine 74 of Proteasome subunit beta type-7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 129 of Proteasome subunit beta type-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 247 of Proteasome subunit beta type-7 and cysteine 150 of Proteasome subunit beta type-3 (204 and 149 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
5a0q
Structure name
cryo-em reveals the conformation of a substrate analogue in the human 20s proteasome core
Structure deposition date
2015-04-22
Thiol separation (Å)
9
Half-sphere exposure sum ?
69
Minimum pKa ?
11
% buried
80
Peptide A name
Proteasome subunit beta type-7
Peptide B name
Proteasome subunit beta type-3
Peptide A accession
Q99436
Peptide B accession
P49720
Peptide A residue number
247
Peptide B residue number
150

Ligandability

Cysteine 247 of Proteasome subunit beta type-7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 150 of Proteasome subunit beta type-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proteasome subunit beta type-7 between cysteines 86 and 87 (43 and 44 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
6htc
Structure name
yeast 20s proteasome with human beta2c (s171g) in complex with onx 0914
Structure deposition date
2018-10-03
Thiol separation (Å)
7
Half-sphere exposure sum ?
96
Minimum pKa ?
13
% buried
100
Peptide accession
Q99436
Residue number A
86
Residue number B
87
Peptide name
Proteasome subunit beta type-7

Ligandability

Cysteine 86 of Proteasome subunit beta type-7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 87 of Proteasome subunit beta type-7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proteasome subunit beta type-7 between cysteines 87 and 219 (44 and 176 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
6tu3
Structure name
rat 20s proteasome
Structure deposition date
2020-01-02
Thiol separation (Å)
8
Half-sphere exposure sum ?
87
Minimum pKa ?
12
% buried
84
Peptide accession
Q9JHW0
Residue number A
87
Residue number B
219
Peptide name
Proteasome subunit beta type-7

Ligandability

Cysteine 87 of Proteasome subunit beta type-7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 219 of Proteasome subunit beta type-7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proteasome subunit beta type-7 between cysteines 86 and 219 (43 and 176 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
24
PDB code
8cxb
Structure name
human pa28-20s (pa28-4a3b)
Structure deposition date
2022-05-20
Thiol separation (Å)
10
Half-sphere exposure sum ?
95
Minimum pKa ?
12
% buried
90
Peptide accession
Q99436
Residue number A
86
Residue number B
219
Peptide name
Proteasome subunit beta type-7

Ligandability

Cysteine 86 of Proteasome subunit beta type-7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 219 of Proteasome subunit beta type-7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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