ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Ethanolamine-phosphate cytidylyltransferase

Intramolecular
Cysteine 27 and cysteine 138
Cysteine 107 and cysteine 110
Cysteine 27 and cysteine 107
Cysteine 27 and cysteine 110
A redox-regulated disulphide may form within Ethanolamine-phosphate cytidylyltransferase between cysteines 27 and 138. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
3elb
Structure name
human ctp: phosphoethanolamine cytidylyltransferase in complex with cmp
Structure deposition date
2008-09-22
Thiol separation (Å)
7
Half-sphere exposure sum ?
74
Minimum pKa ?
11
% buried
78
Peptide accession
Q99447
Residue number A
27
Residue number B
138
Peptide name
Ethanolamine-phosphate cytidylyltransferase

Ligandability

Cysteine 27 of Ethanolamine-phosphate cytidylyltransferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 138 of Ethanolamine-phosphate cytidylyltransferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ethanolamine-phosphate cytidylyltransferase between cysteines 107 and 110. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
3elb
Structure name
human ctp: phosphoethanolamine cytidylyltransferase in complex with cmp
Structure deposition date
2008-09-22
Thiol separation (Å)
9
Half-sphere exposure sum ?
78
Minimum pKa ?
11
% buried
68
Peptide accession
Q99447
Residue number A
107
Residue number B
110
Peptide name
Ethanolamine-phosphate cytidylyltransferase

Ligandability

Cysteine 107 of Ethanolamine-phosphate cytidylyltransferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 110 of Ethanolamine-phosphate cytidylyltransferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ethanolamine-phosphate cytidylyltransferase between cysteines 27 and 107. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
3elb
Structure name
human ctp: phosphoethanolamine cytidylyltransferase in complex with cmp
Structure deposition date
2008-09-22
Thiol separation (Å)
9
Half-sphere exposure sum ?
83
Minimum pKa ?
11
% buried
80
Peptide accession
Q99447
Residue number A
27
Residue number B
107
Peptide name
Ethanolamine-phosphate cytidylyltransferase

Ligandability

Cysteine 27 of Ethanolamine-phosphate cytidylyltransferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 107 of Ethanolamine-phosphate cytidylyltransferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ethanolamine-phosphate cytidylyltransferase between cysteines 27 and 110. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
3elb
Structure name
human ctp: phosphoethanolamine cytidylyltransferase in complex with cmp
Structure deposition date
2008-09-22
Thiol separation (Å)
8
Half-sphere exposure sum ?
94
Minimum pKa ?
12
% buried
88
Peptide accession
Q99447
Residue number A
27
Residue number B
110
Peptide name
Ethanolamine-phosphate cytidylyltransferase

Ligandability

Cysteine 27 of Ethanolamine-phosphate cytidylyltransferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 110 of Ethanolamine-phosphate cytidylyltransferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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