26S proteasome non-ATPase regulatory subunit 1
Intramolecular
Cysteine 806 and cysteine 898 L
Cysteine 633 and cysteine 659 L
Cysteine 184 and cysteine 219
Cysteine 659 and cysteine 660
Cysteine 633 and cysteine 660 L
Cysteine 104 and cysteine 112
Cysteine 217 and cysteine 219
Cysteine 217 and cysteine 249
Cysteine 591 and cysteine 659
6epc N 806 N 898
A redox-regulated disulphide may form within 26S proteasome non-ATPase regulatory subunit 1 between cysteines 806 and 898.
Details
Redox score ?
81
PDB code
6epc
Structure name
ground state 26s proteasome (gs2)
Structure deposition date
2017-10-11
Thiol separation (Å)
3
Half-sphere exposure sum ?
61
Minimum pKa ?
6
% buried
56
Peptide accession
O88761
Residue number A
806
Residue number B
898
Peptide name
26S proteasome non-ATPase regulatory subunit 1
Ligandability
Cysteine 806 of 26S proteasome non-ATPase regulatory subunit 1
Cysteine 898 of 26S proteasome non-ATPase regulatory subunit 1
5t0j U 633 U 659
A redox-regulated disulphide may form within 26S proteasome non-ATPase regulatory subunit 1 between cysteines 633 and 659.
Details
Redox score ?
72
PDB code
5t0j
Structure name
structural basis for dynamic regulation of the human 26s proteasome
Structure deposition date
2016-08-16
Thiol separation (Å)
3
Half-sphere exposure sum ?
86
Minimum pKa ?
9
% buried
90
Peptide accession
Q99460
Residue number A
633
Residue number B
659
Peptide name
26S proteasome non-ATPase regulatory subunit 1
Ligandability
Cysteine 633 of 26S proteasome non-ATPase regulatory subunit 1
Cysteine 659 of 26S proteasome non-ATPase regulatory subunit 1
5l4k N 184 N 219
A redox-regulated disulphide may form within 26S proteasome non-ATPase regulatory subunit 1 between cysteines 184 and 219. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
51
PDB code
5l4k
Structure name
the human 26s proteasome lid
Structure deposition date
2016-05-25
Thiol separation (Å)
7
Half-sphere exposure sum ?
71
Minimum pKa ?
11
% buried
78
Peptide accession
Q99460
Residue number A
184
Residue number B
219
Peptide name
26S proteasome non-ATPase regulatory subunit 1
Ligandability
Cysteine 184 of 26S proteasome non-ATPase regulatory subunit 1
Cysteine 219 of 26S proteasome non-ATPase regulatory subunit 1
5ln3 N 659 N 660
A redox-regulated disulphide may form within 26S proteasome non-ATPase regulatory subunit 1 between cysteines 659 and 660. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
5ln3
Structure name
the human 26s proteasome at 6
Structure deposition date
2016-08-03
Thiol separation (Å)
7
Half-sphere exposure sum ?
83
Minimum pKa ?
12
% buried
83
Peptide accession
Q99460
Residue number A
659
Residue number B
660
Peptide name
26S proteasome non-ATPase regulatory subunit 1
Ligandability
Cysteine 659 of 26S proteasome non-ATPase regulatory subunit 1
Cysteine 660 of 26S proteasome non-ATPase regulatory subunit 1
5vgz U 633 U 660
A redox-regulated disulphide may form within 26S proteasome non-ATPase regulatory subunit 1 between cysteines 633 and 660. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
5vgz
Structure name
conformational landscape of the p28-bound human proteasome regulatory particle
Structure deposition date
2017-04-12
Thiol separation (Å)
9
Half-sphere exposure sum ?
79
Minimum pKa ?
8
% buried
80
Peptide accession
Q99460
Residue number A
633
Residue number B
660
Peptide name
26S proteasome non-ATPase regulatory subunit 1
Ligandability
Cysteine 633 of 26S proteasome non-ATPase regulatory subunit 1
Cysteine 660 of 26S proteasome non-ATPase regulatory subunit 1
5t0g U 104 U 112
A redox-regulated disulphide may form within 26S proteasome non-ATPase regulatory subunit 1 between cysteines 104 and 112. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
5t0g
Structure name
structural basis for dynamic regulation of the human 26s proteasome
Structure deposition date
2016-08-16
Thiol separation (Å)
10
Half-sphere exposure sum ?
63
Minimum pKa ?
10
% buried
68
Peptide accession
Q99460
Residue number A
104
Residue number B
112
Peptide name
26S proteasome non-ATPase regulatory subunit 1
Ligandability
Cysteine 104 of 26S proteasome non-ATPase regulatory subunit 1
Cysteine 112 of 26S proteasome non-ATPase regulatory subunit 1
5vgz U 217 U 219
A redox-regulated disulphide may form within 26S proteasome non-ATPase regulatory subunit 1 between cysteines 217 and 219. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
5vgz
Structure name
conformational landscape of the p28-bound human proteasome regulatory particle
Structure deposition date
2017-04-12
Thiol separation (Å)
8
Half-sphere exposure sum ?
76
Minimum pKa ?
12
% buried
86
Peptide accession
Q99460
Residue number A
217
Residue number B
219
Peptide name
26S proteasome non-ATPase regulatory subunit 1
Ligandability
Cysteine 217 of 26S proteasome non-ATPase regulatory subunit 1
Cysteine 219 of 26S proteasome non-ATPase regulatory subunit 1
5l4k N 217 N 249
A redox-regulated disulphide may form within 26S proteasome non-ATPase regulatory subunit 1 between cysteines 217 and 249. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
33
PDB code
5l4k
Structure name
the human 26s proteasome lid
Structure deposition date
2016-05-25
Thiol separation (Å)
8
Half-sphere exposure sum ?
86
Minimum pKa ?
13
% buried
100
Peptide accession
Q99460
Residue number A
217
Residue number B
249
Peptide name
26S proteasome non-ATPase regulatory subunit 1
Ligandability
Cysteine 217 of 26S proteasome non-ATPase regulatory subunit 1
Cysteine 249 of 26S proteasome non-ATPase regulatory subunit 1
5ln3 N 591 N 659
A redox-regulated disulphide may form within 26S proteasome non-ATPase regulatory subunit 1 between cysteines 591 and 659. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
29
PDB code
5ln3
Structure name
the human 26s proteasome at 6
Structure deposition date
2016-08-03
Thiol separation (Å)
10
Half-sphere exposure sum ?
83
Minimum pKa ?
12
% buried
92
Peptide accession
Q99460
Residue number A
591
Residue number B
659
Peptide name
26S proteasome non-ATPase regulatory subunit 1
Ligandability
Cysteine 591 of 26S proteasome non-ATPase regulatory subunit 1
Cysteine 659 of 26S proteasome non-ATPase regulatory subunit 1
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