ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Nuclear pore complex protein Nup88

Intramolecular
Cysteine 103 and cysteine 155
Cysteine 316 and cysteine 319
Cysteine 368 and cysteine 447 L
Cysteine 319 and cysteine 401
Cysteine 391 and cysteine 407
Cysteine 312 and cysteine 391
Cysteine 482 and cysteine 489
Cysteine 312 and cysteine 407
A redox-regulated disulphide may form within Nuclear pore complex protein Nup88 between cysteines 103 and 155. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
7mni
Structure name
crystal structure of the n-terminal domain of nup88 in complex with nup98 c-terminal autoproteolytic domain
Structure deposition date
2021-05-01
Thiol separation (Å)
7
Half-sphere exposure sum ?
61
Minimum pKa ?
12
% buried
80
Peptide accession
Q99567
Residue number A
103
Residue number B
155
Peptide name
Nuclear pore complex protein Nup88

Ligandability

Cysteine 103 of Nuclear pore complex protein Nup88

Cysteine 155 of Nuclear pore complex protein Nup88

A redox-regulated disulphide may form within Nuclear pore complex protein Nup88 between cysteines 316 and 319. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
7mni
Structure name
crystal structure of the n-terminal domain of nup88 in complex with nup98 c-terminal autoproteolytic domain
Structure deposition date
2021-05-01
Thiol separation (Å)
7
Half-sphere exposure sum ?
71
Minimum pKa ?
11
% buried
86
Peptide accession
Q99567
Residue number A
316
Residue number B
319
Peptide name
Nuclear pore complex protein Nup88

Ligandability

Cysteine 316 of Nuclear pore complex protein Nup88

Cysteine 319 of Nuclear pore complex protein Nup88

A redox-regulated disulphide may form within Nuclear pore complex protein Nup88 between cysteines 368 and 447. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
7mni
Structure name
crystal structure of the n-terminal domain of nup88 in complex with nup98 c-terminal autoproteolytic domain
Structure deposition date
2021-05-01
Thiol separation (Å)
9
Half-sphere exposure sum ?
54
Minimum pKa ?
10
% buried
50
Peptide accession
Q99567
Residue number A
368
Residue number B
447
Peptide name
Nuclear pore complex protein Nup88

Ligandability

Cysteine 368 of Nuclear pore complex protein Nup88

Cysteine 447 of Nuclear pore complex protein Nup88

A redox-regulated disulphide may form within Nuclear pore complex protein Nup88 between cysteines 319 and 401. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
7mni
Structure name
crystal structure of the n-terminal domain of nup88 in complex with nup98 c-terminal autoproteolytic domain
Structure deposition date
2021-05-01
Thiol separation (Å)
9
Half-sphere exposure sum ?
51
Minimum pKa ?
9
% buried
48
Peptide accession
Q99567
Residue number A
319
Residue number B
401
Peptide name
Nuclear pore complex protein Nup88

Ligandability

Cysteine 319 of Nuclear pore complex protein Nup88

Cysteine 401 of Nuclear pore complex protein Nup88

A redox-regulated disulphide may form within Nuclear pore complex protein Nup88 between cysteines 391 and 407. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
7mni
Structure name
crystal structure of the n-terminal domain of nup88 in complex with nup98 c-terminal autoproteolytic domain
Structure deposition date
2021-05-01
Thiol separation (Å)
8
Half-sphere exposure sum ?
73
Minimum pKa ?
11
% buried
74
Peptide accession
Q99567
Residue number A
391
Residue number B
407
Peptide name
Nuclear pore complex protein Nup88

Ligandability

Cysteine 391 of Nuclear pore complex protein Nup88

Cysteine 407 of Nuclear pore complex protein Nup88

A redox-regulated disulphide may form within Nuclear pore complex protein Nup88 between cysteines 312 and 391. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
7mni
Structure name
crystal structure of the n-terminal domain of nup88 in complex with nup98 c-terminal autoproteolytic domain
Structure deposition date
2021-05-01
Thiol separation (Å)
8
Half-sphere exposure sum ?
71
Minimum pKa ?
11
% buried
68
Peptide accession
Q99567
Residue number A
312
Residue number B
391
Peptide name
Nuclear pore complex protein Nup88

Ligandability

Cysteine 312 of Nuclear pore complex protein Nup88

Cysteine 391 of Nuclear pore complex protein Nup88

A redox-regulated disulphide may form within Nuclear pore complex protein Nup88 between cysteines 482 and 489. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
7mni
Structure name
crystal structure of the n-terminal domain of nup88 in complex with nup98 c-terminal autoproteolytic domain
Structure deposition date
2021-05-01
Thiol separation (Å)
9
Half-sphere exposure sum ?
77
Minimum pKa ?
12
% buried
87
Peptide accession
Q99567
Residue number A
482
Residue number B
489
Peptide name
Nuclear pore complex protein Nup88

Ligandability

Cysteine 482 of Nuclear pore complex protein Nup88

Cysteine 489 of Nuclear pore complex protein Nup88

A redox-regulated disulphide may form within Nuclear pore complex protein Nup88 between cysteines 312 and 407. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
7mni
Structure name
crystal structure of the n-terminal domain of nup88 in complex with nup98 c-terminal autoproteolytic domain
Structure deposition date
2021-05-01
Thiol separation (Å)
8
Half-sphere exposure sum ?
88
Minimum pKa ?
12
% buried
96
Peptide accession
Q99567
Residue number A
312
Residue number B
407
Peptide name
Nuclear pore complex protein Nup88

Ligandability

Cysteine 312 of Nuclear pore complex protein Nup88

Cysteine 407 of Nuclear pore complex protein Nup88

If this tool was useful for finding a disulphide, please cite: